| 刘小虎,徐永建,夏云连.多发性肝癌肝切除术患者远期预后的影响因素分析.[J].中南医学科学杂志.,2023,(4):599-602. |
| 多发性肝癌肝切除术患者远期预后的影响因素分析 |
| Influencing factors of long-term prognosis in patients with multiple hepatocellular carcinomas undergoing hepatectomy |
| 投稿时间：2022-09-02 修订日期：2022-12-23 |
| DOI：10.15972/j.cnki.43-1509/r.2023.04.032 |
| 中文关键词: 多发性肝癌 肝切除术 远期预后 影响因素 累积生存率 [ |
| 英文关键词:multiple liver cancer liver resection long-term prognosis influencing factors cumulative survival rate |
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| 中文摘要: |
| 目的探讨多发性肝癌肝切除术患者远期预后的影响因素。 方法纳入多发性肝癌患者102例开展回顾性研究,均行肝切除术,记录并计算患者的中位生存时间、总生存期以及1、2、4年的累积生存率。经多元Cox回归模型分析患者远期预后的影响因素。 结果102例患者的中位生存时间为42个月,总生存期为32个月,1、2、4年的累积生存率分别为79.57%、64.52%和44.09%。多元Cox回归分析提示临床分期Ⅲa期、肿瘤最大直径＞5 cm、病灶数量≥4个、门脉瘤栓、微血管侵犯是多发性肝癌患者预后的独立危险因素(P＜0.05),而肿瘤包膜完整、术后辅助治疗是术后生存的保护性因素(P＜0.05)。 结论多发性肝癌行肝切除术后远期疗效仍不够理想,患者远期预后主要与临床分期、肿瘤大小、病灶数量、门脉瘤栓、肿瘤包膜是否完整、微血管侵犯、术后辅助治疗有关。 |
| 英文摘要: |
| AimTo investigate the influencing factors of long-term prognosis in patients with multiple liver cancer who underwent liver resection. MethodsA retrospective study was conducted on 102 patients with multiple liver cancer. All of them underwent hepatectomy and were followed up for 12－48 months. Median survival time, overall survival time, and 1,2, and 4 years' cumulative survival rate were recorded and calculated. Multivariate Cox regression model was used to analyze the influencing factors of long-term prognosis. ResultsThe median survival time of 102 patients was 42 months, and the overall survival time was 32 months. The cumulative survival rates of 1,2, and 4 years were 79.57%, 64.52%, and 44.09%, respectively. Multivariate Cox regression analysis showed that clinical stage Ⅲa, the largest tumor diameter ＞5 cm, the number of lesions ≥4, portal aneurysm thrombus, and microvascular invasion were independent risk factors for the prognosis of patients with multiple liver cancer (P＜0.05), whereas postoperative adjuvant therapy was a protective factor for postoperative survival (P＜0.05). ConclusionThe long-term efficacy of multiple liver cancer after hepatectomy is still not ideal.The long-term prognosis of patients is mainly related to clinical stage, tumor size, number of lesions, portal vein tumor thrombus, tumor capsule integrity, microvascular invasion, and postoperative adjuvant therapy. |
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