| 李妙洪,何美霞,黄小娟.妊娠期孕妇GBS感染及预防性抗生素干预对妊娠结局的影响.[J].中南医学科学杂志.,2023,(4):585-588. |
| 妊娠期孕妇GBS感染及预防性抗生素干预对妊娠结局的影响 |
| GBS infection in pregnant women and the effects of prophylactic antibiotic intervention during delivery on pregnancy outcome |
| 投稿时间：2022-12-08 修订日期：2023-02-18 |
| DOI：10.15972/j.cnki.43-1509/r.2023.04.028 |
| 中文关键词: 妊娠 B族链球菌 抗生素 妊娠结局 新生儿结局 [ |
| 英文关键词:pregnancy group B streptococcus antibiotics pregnancy outcomes neonatal outcomes |
| 基金项目:崇左市科技计划项目(崇科政2020016) |
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| 中文摘要: |
| 目的观察妊娠期孕妇B族链球菌(GBS)感染情况及分娩时预防性抗生素干预对妊娠结局的影响。 方法将255例妊娠期孕妇按照GBS感染情况分为GBS阳性组85例及GBS阴性组170例,根据分娩时是否给与预防性抗生素干预,将GBS阳性孕妇分为抗生素组42例及对照组43例。比较GBS阳性组、GBS阴性组及抗生素组、对照组的妊娠结局(早产、胎膜早破、宫内感染、产褥感染)及新生儿结局(胎儿窘迫、新生儿感染、新生儿高胆红素血症)情况,并分析GBS菌株的耐药性。 结果GBS阳性组早产、胎膜早破、宫内感染、产褥感染以及胎儿窘迫、新生儿感染、新生儿高胆红素血症发生率均高于GBS阴性组(P＜0.05)；抗生素组胎膜早破、宫内感染、产褥感染以及新生儿感染、新生儿高胆红素血症发生率均低于对照组(P＜0.05)。GBS菌株对青霉素G、万古霉素、氨苄青霉素的敏感性最高,均为100.00%,对红霉素的耐药性最高,为43.53%。 结论GBS感染会增加妊娠及新生儿不良结局,于分娩时给与预防性抗生素治疗能有效改善孕妇妊娠结局及新生儿结局。 |
| 英文摘要: |
| AimTo observe the infection of Group B streptococcus (GBS) in pregnant women and the effects of prophylactic antibiotic intervention during delivery on pregnancy outcome. MethodsAccording to the situation of GBS infection, 255 pregnant women in our hospital were divided into GBS positive group (85 cases) and GBS negative group (170 cases). According to whether prophylactic antibiotics intervention was given during delivery, GBS positive pregnant women were divided into antibiotic group (42 cases) and control group (43 cases). The pregnancy outcomes (premature delivery, premature rupture of membranes, intrauterine infection, puerperal infection) and neonatal outcomes (fetal distress, pathological jaundice, neonatal infection and neonatal hyperbilirubinemia) of GBS positive group, GBS negative group, antibiotic group and control group were compared, and the drug resistance of GBS strains was analyzed. ResultsThe rates of preterm delivery, premature rupture of membranes, intrauterine infection, puerperal infection, fetal distress, neonatal infection and neonatal hyperbilirubinemia in GBS positive group were higher than those in GBS negative group (P＜0.05). The incidence of premature rupture of membranes, intrauterine infection, puerperal infection, neonatal infection and neonatal hyperbilirubinemia in antibiotic group was lower than that in control group (P＜0.05). The sensitivity of GBS to penicillin G, Vancomycin and ampicillin was the highest (100.00%), and the resistance to erythromycin was the highest (43.53%). ConclusionGBS infection can increase pregnancy and neonatal adverse outcomes, prophylactic antibiotics during delivery can effectively improve maternal pregnancy outcomes and neonatal outcomes. |
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