| 毕松杰,张成伟,尹锐,贾国渠.STEMI患者PCI术后血清PDGF、Ang-1水平与预后的关系.[J].中南医学科学杂志.,2023,(4):564-567. |
| STEMI患者PCI术后血清PDGF、Ang-1水平与预后的关系 |
| The relationship between serum PDGF, Ang-1 and prognosis in STEMI patients after PCI |
| 投稿时间：2022-09-29 修订日期：2023-05-30 |
| DOI：10.15972/j.cnki.43-1509/r.2023.04.022 |
| 中文关键词: 急性ST段抬高型心肌梗死 经皮冠状动脉介入术 血小板源性生长因子 血管生成素-1 预后 [ |
| 英文关键词:STEMI PCI platelet derived growth factor angiopoietin-1 prognosis |
| 基金项目:成都市科技项目(2022-YF05-01459-SN) |
|
| 摘要点击次数: 158 |
| 全文下载次数: 117 |
| 中文摘要: |
| 目的探讨急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入术(PCI)后血清血小板源性生长因子(PDGF)、血管生成素-1(Ang-1)水平与预后的关系。 方法选取行PCI治疗的STEMI患者126例,根据术后主要不良心血管事件(MACE)分为预后不良组和预后良好组。采用ELISA法检测血清PDGF、Ang-1水平,比较不同PDGF、Ang-1水平患者的预后情况。采用Cox风险回归模型分析STEMI预后不良的影响因素。采用ROC曲线分析PDGF、Ang-1对STEMI患者预后的预测价值。 结果预后不良组PDGF、Ang-1高于预后良好组(P＜0.05)。高PDGF组与高Ang-1组患者MACE发生率高于低PDGF组、低Ang-1组(P＜0.05)。多支病变、高PDGF、高Ang-1均是STEMI患者预后不良的危险因素(P＜0.05)。血清PDGF、Ang-1对STEMI患者预后的预测效能较高。 结论高PDGF、Ang-1水平STEMI患者PCI术后更易发生MACE,二者有望作为预测STEMI患者预后的有效生物标志物。 |
| 英文摘要: |
| AimTo explore the relationship between serum levels of platelet derived growth factor (PDGF) and angiopoietin-1 (Ang-1) and prognosis in patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). Methods126 STEMI patients who underwent PCI treatment were selected and divided into a poor prognosis group and a good prognosis group based on the main adverse cardiovascular events (MACE) after surgery. ELISA was used to detect serum levels of PDGF and Ang-1, and the prognosis of patients with different levels of PDGF and Ang-1 was compared. Cox risk regression model was used to analyze the related factors that affect the poor prognosis of STEMI. Receiver operating characteristic was used to evaluate the prognostic value of serum PDGF and Ang-1 in patients with STEMI. ResultsThe PDGF and Ang-1 levels in the poor prognosis group were higher than those in the good prognosis group (P＜0.05). The incidence of MACE in patients with high PDGF and high Ang-1 was higher than that in patients with low PDGF and low Ang-1 (P＜0.05). Multiple vessel lesions, high PDGF, and high Ang-1 are all risk factors for poor prognosis in STEMI patients (P＜0.05). The predictive efficacy of serum PDGF and Ang-1 for the prognosis of STEMI patients is relatively high. ConclusionSTEMI patients with high levels of PDGF and Ang-1 are more likely to develop MACE after PCI, and these molecules are expected to serve as effective biomarkers for predicting the prognosis of STEMI patients. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |