| 袁志英,苗晓红.术前髂内动脉栓塞灌注化疗对早期宫颈癌组织HIF-1α、JMJD2B及病灶血流灌注的影响.[J].中南医学科学杂志.,2023,(4):532-536. |
| 术前髂内动脉栓塞灌注化疗对早期宫颈癌组织HIF-1α、JMJD2B及病灶血流灌注的影响 |
| Effects of preoperative internal iliac artery chemoembolization on lesion blood perfusion, HIF-1 α, JMJD2B of early cervical cancer |
| 投稿时间：2022-03-04 修订日期：2023-05-20 |
| DOI：10.15972/j.cnki.43-1509/r.2023.04.014 |
| 中文关键词: 早期宫颈癌 髂内动脉栓塞灌注化疗 HIF-1α JMJD2B 病灶血流灌注 [ |
| 英文关键词:early cervical cancer internal iliac artery chemoembolization HIF-1 α JMJD2B lesion blood perfusion |
| 基金项目:河北省医学科学研究课题计划(20211132) |
|
| 摘要点击次数: 162 |
| 全文下载次数: 127 |
| 中文摘要: |
| 目的探讨术前髂内动脉栓塞灌注化疗对早期宫颈癌(CC)组织缺氧诱导因子-1α(HIF-1α)、含Jumonji结构域蛋白2B(JMJD2B)及病灶血流灌注的影响。 方法选取92例CC患者,按照治疗方法分为对照组(全身静脉化疗)和观察组(髂内动脉栓塞灌注化疗)。比较两组化疗前、后CC组织HIF-1α、JMJD2B表达水平和表达阳性率、病灶血流灌注情况、疗效及根治性子宫切除术后5年复发情况。 结果与化疗前比较,化疗后两组HIF-1α、JMJD2B mRNA表达、上升时间、峰值强度、HIF-1α和JMJD2B蛋白表达阳性率均降低,达峰时间、平均通过时间升高,且观察组较对照组更为显著(P＜0.05)。观察组总有效率高于对照组(P＜0.05)。观察组术后5年无进展生存期长于对照组(P＜0.05)。 结论术前髂内动脉栓塞灌注化疗可有效降低CC患者病灶血流灌注,下调HIF-1α、JMJD2B表达,有利于提升疗效和改善预后。 |
| 英文摘要: |
| AimTo investigate the effects of preoperative internal iliac artery embolization and perfusion chemotherapy on hypoxia-inducible factor-1α (HIF-1α), Jumonji domain-containing protein 2B (JMJD2B) and lesion blood perfusion in early cervical cancer (CC). Methods92 patients with CC were divided into control group (systemic intravenous chemotherapy) and observation group (internal iliac artery infusion embolization chemotherapy) according to the treatment methods. HIF-1α in CC tissues before and after chemotherapy, the expression level and positive rate of JMJD2B, the perfusion of lesion blood flow, efficacy, and 5-year recurrence after radical hysterectomy in the two groups were compared. ResultsAfter chemotherapy, the expression, rising time, peak intensity of HIF-1α and JMJD2B mRNA, as well as the positive expression rates of HIF-1α, JMJD2B and JMJD2B proteins were decreased, and accordingly the peak time and average passage time were increased. The observation group was more significant than the control group (P＜0.05). The total effective rate of the observation group was higher than that of the control group (P＜0.05). The 5-year progression free survival period in the observation group was longer than that in the control group (P＜0.05). ConclusionPreoperative internal iliac artery chemoembolization and perfusion can effectively reduce the focus blood flow perfusion of CC patients and down regulate HIF-1 α. The expression of JMJD2B is beneficial for improving efficacy and prognosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|