| 崔娟,于新宇,孙晓平,苏莉.沙库巴曲缬沙坦钠联合达格列净片对T2DM合并HF患者血清NT-proBNP、心肌重塑及血糖控制的影响.[J].中南医学科学杂志.,2023,(4):524-527. |
| 沙库巴曲缬沙坦钠联合达格列净片对T2DM合并HF患者血清NT-proBNP、心肌重塑及血糖控制的影响 |
| Effects of sacubarb valsartan sodium combined with dapagliflozin tablets on serum NT-proBNP, myocardial reconstitution and FBG control in patients with T2DM and HF |
| 投稿时间：2023-02-14 修订日期：2023-05-20 |
| DOI：10.15972/j.cnki.43-1509/r.2023.04.012 |
| 中文关键词: T2DM HF 沙库巴曲缬沙坦钠 达格列净片 心肌重塑 NT-proBNP [ |
| 英文关键词:T2DM HF sarkozy valsartan sodium dapagliflozin films myocardial remodeling NT-proBNP |
| 基金项目:山东省自然科学基金项目(2021CFB188) |
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| 中文摘要: |
| 目的观察沙库巴曲缬沙坦钠联合达格列净片对2型糖尿病(T2DM)合并心力衰竭(HF)患者血清N末端脑钠肽前体(NT-proBNP)、心肌重塑及血糖控制的影响。 方法将218例T2DM合并HF患者分为观察组110例和对照组108例。对照组应用达格列净片,观察组在此基础上增服沙库巴曲缬沙坦钠。比较两组治疗前后血清NT-proBNP、左心室射血分数(LVEF)、心室重塑情况、日常生活活动能力量表(ADL)评分、空腹血糖(FBG)和糖化血红蛋白(HbA1c)水平。对比两组治疗1年内因HF再入院率、主要不良心血管事件(MACE)发生率和全因死亡率。 结果治疗后,两组NT-proBNP、左心室质量指数水平、FBG和HbA1c较治疗前降低,且观察组低于对照组；而LVEF、左心室重构指数水平、ADL评分较治疗前升高,且观察组高于对照组(P＜0.05)。观察组HF再入院率、MACE发生率和全因死亡率均低于对照组(P＜0.05)。 结论沙库巴曲缬沙坦钠联合达格列净片有助于控制T2DM合并HF患者血糖水平,提高其心功能,逆转心肌重塑,改善日常活动能力,安全性高,值得推广。 |
| 英文摘要: |
| AimTo compare the effects of sarkozy valsartan sodium combined with dapagliflozin tablets on serum NT-proBNP, myocardial remodeling and blood glucose control in patients with type 2 diabetes mellitus (T2DM) complicated with heart failure (HF). MethodsA total of 218 patients with T2DM combined with HF were randomly divided into an observation group of 110 cases and a control group of 108 cases. Patients in the control group were treated with dapagliflozin tablets, while those in the observation group were additionally administrated with sabcomeline valsartan sodium. Serum NT-proBNP, left ventricular ejection fraction (LVEF), activity of daily living (ADL) score, fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) levels were compared between the two groups before and after treatment. The readmission rate of HF, the incidence of major adverse cardiovascular events (MACE) and all-cause mortality were compared between the two groups within one year treatment. ResultsAfter treatment, the levels of NT-proBNP, left ventricular mass index (LVMI), FBG and HbA1c in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group. The LVEF, left ventricular remodeling index (LVRI), and ADL scores were higher in the observation group than those in the control group (P＜0.05). The incidence of HF readmission, MACE and all-cause mortality in the observation group were lower than those in the control group (P＜0.05). ConclusionThe combination of dapagliflozin tablets and sabcomeline valsartan sodium is helpful to control the blood glucose level of T2DM patients combined with HF, improve their cardiac function, reverse myocardial remodeling, improve daily activity, and reduce the rehospitalization rate of HF and the risk of MACE. It is safe and worthy of promotion. |
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