| 李雪芳,陈威,谢安娜,杨佳雯,李国庆,杨南扬.基于生物信息学分析ZNF217在低级别胶质瘤中表达的临床意义.[J].中南医学科学杂志.,2023,(4):497-501. |
| 基于生物信息学分析ZNF217在低级别胶质瘤中表达的临床意义 |
| The clinical significance of ZNF217 expression in low-grade gliomas based on bioinformatics analysis |
| 投稿时间：2022-11-29 修订日期：2023-04-06 |
| DOI：10.15972/j.cnki.43-1509/r.2023.04.006 |
| 中文关键词: ZNF217 低级别胶质瘤 生物信息学 预后 [ |
| 英文关键词:ZNF217 low-grade glioma bioinformatics prognosis |
| 基金项目:国家自然科学基金(81602249)；湖南省自然科学基金(2021JJ40480)；湖南省教育厅优秀青年项目(19B500)；国家级大学生创新创业训练计划项目(202110555097)；湖南省大学生创新创业训练计划项目(20212837) |
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| 中文摘要: |
| 目的利用生物信息学分析ZNF217在低级别胶质瘤(LGG)中表达的临床意义。 方法通过GEPIA、HPA、UALCAN、CGGA、TIMER2.0、cBioPortal和LinkedOmics等数据库对低级别胶质瘤患者ZNF217的差异表达、临床病理特征、预后价值、免疫细胞浸润、基因突变和启动子甲基化水平进行分析。 结果LGG组织中ZNF217 mRNA和蛋白表达水平较正常组织上调(P＜0.05),ZNF217 mRNA表达水平与患者的肿瘤分级、免疫细胞浸润及相关标志物呈正相关(P＜0.05),与患者总生存期和无病生存期呈负相关(P＜0.05)。ZNF217发生基因突变和启动子低甲基化(P＜0.05),进而导致LGG患者预后不良(P＜0.05)。 结论ZNF217在LGG中表达上调,其高表达与LGG患者预后不良有关,ZNF217可能成为LGG预后生物标志物和潜在的治疗靶点。 |
| 英文摘要: |
| AimTo analyze the expression and clinical significance of ZNF217 in low-grade gliomas (LGG) by bioinformatics. MethodsGEPIA, HPA, UALCAN, CGGA, TIMER2.0, cBioPortal, and LinkedOmics databases were used to analyze the differential expression, clinical pathological characteristics, prognostic value, immune cell infiltration results, gene mutations, and promoter methylation levels of ZNF217 in patients with low-grade glioma. ResultsThe mRNA and protein expression levels of ZNF217 in LGG tissues were upregulated compared with normal tissues (P＜0.05), and ZNF217 mRNA expression levels were positively correlated with tumor grade, immune cell infiltration, and related markers in patients (P＜0.05), while negatively correlated with overall survival and disease-free survival in patients (P＜0.05). ZNF217 showed gene mutations and promoter hypomethylation (P＜0.05), leading to poor prognosis in LGG patients (P＜0.05). ConclusionZNF217 was up-regulated in LGG, and its high expression was related to poor prognosis of LGG patients, indicating ZNF217 could be a prognostic biomarker in LGG and potential therapeutic target for LGG. |
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