| 陶颖,周利.戊酸雌二醇联合黄体酮治疗围绝经期功能性子宫出血疗效及对bFGF、VEGF的影响.[J].中南医学科学杂志.,2023,(3):445-447. |
| 戊酸雌二醇联合黄体酮治疗围绝经期功能性子宫出血疗效及对bFGF、VEGF的影响 |
| The efficacy of estradiol valerate combined with progesterone in the treatment of functional uterine bleeding during perimenopause and its impact on bFGF and VEGF |
| 投稿时间：2021-12-28 修订日期：2022-12-08 |
| DOI：10.15972/j.cnki.43-1509/r.2023.03.032 |
| 中文关键词: 戊酸雌二醇 黄体酮 围绝经期 功能性子宫出血 [ |
| 英文关键词:estradiol valerate progesterone perimenopausal period functional uterine bleeding |
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| 中文摘要: |
| 目的探讨戊酸雌二醇联合黄体酮治疗围绝经期功能性子宫出血(FUB)疗效及对碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)的影响。 方法选择围绝经期FUB患者120例,随机均分为对照组(黄体酮)和联合组(戊酸雌二醇加黄体酮),比较两组治疗总有效率、性激素水平、抗米勒管激素(AMH)、bFGF、VEGF、止血时间、控制出血时间及并发症发生率。 结果联合组治疗总有效率高于对照组,止血时间、控制出血时间短于对照组(P＜0.05);两组并发症发生率差异无显著性(P＞0.05)。与治疗前比较,治疗后两组雌二醇、泌乳素、bFGF、VEGF及AMH均升高,促黄体素、孕酮、卵泡刺激素、睾酮降低；且联合组较对照组变化更为明显(P＜0.05)。 结论戊酸雌二醇联合黄体酮治疗可提高围绝经期FUB患者的临床疗效。 |
| 英文摘要: |
| AimExplore the efficacy of estradiol valerate combined with progesterone in the treatment of functional uterine bleeding (FUB) during perimenopause and its impact on basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). Methods120 patients with FUB during perimenopause were selected and randomly divided into a control group (progesterone) and a combination group (estradiol valerate and progesterone). The total effective rate, sex hormone levels, anti miller's hormone (AMH), bFGF, VEGF, hemostatic time, bleeding control time, and incidence of complications were compared between the two groups. ResultsThe total effective rate of the combined group was higher than that of the control group, and the hemostasis time and bleeding control time were shorter than those of the control group (P＜0.05); There was no significant difference in the incidence of complications between the two groups (P＞0.05). After treatment, estradiol, prolactin, bFGF, VEGF and AMH increased, while luteinizing hormone, progesterone, follicle stimulating hormone and testosterone decreased; And the combined group showed more significant changes compared to the control group (P＜0.05). ConclusionThe combination of estradiol valerate and progesterone can improve the clinical efficacy of patients with FUB during perimenopause. |
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