| 徐琦.血清IL-17A、TGF-β对高级别CIN患者术后复发的预测价值.[J].中南医学科学杂志.,2023,(3):406-409. |
| 血清IL-17A、TGF-β对高级别CIN患者术后复发的预测价值 |
| The predictive value of serum IL-17A and TGF-β for postoperative recurrence in high-grade CIN patients |
| 投稿时间：2022-03-28 修订日期：2023-03-28 |
| DOI：10.15972/j.cnki.43-1509/r.2023.03.022 |
| 中文关键词: 宫颈上皮内瘤变 复发 白细胞介素17A 转化生长因子β [ |
| 英文关键词:cervical intraepithelial neoplasia recurrence interleukin-17A transforming growth factor β |
| 基金项目:吴阶平医学基金会临床科研专项资助基金(320.6750.18086) |
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| 中文摘要: |
| 目的分析血清白细胞介素(IL)-17A、转化生长因子-β(TGF-β)对高级别宫颈上皮内瘤变(CIN)患者术后复发的预测价值。 方法选取223例行宫颈锥切术的高级别CIN患者,随访1年,根据复发情况分为复发组与未复发组。多因素Logistic回归分析血清IL-17A、TGF-β水平与高级别CIN患者术后复发的关系。ROC曲线分析IL-17A、TGF-β预测高级别CIN患者术后复发的价值。决策曲线分析指标联合的预测价值。 结果复发组血清IL-17A、TGF-β水平高于未复发组(P＜0.05)；回归分析结果显示,术前血清高水平IL-17A、TGF-β为术后复发的危险因素(P＜0.05)；ROC曲线显示,术前血清IL-17A、TGF-β预测术后复发风险的AUC均＞0.80；决策曲线显示,联合预测优于单独预测。 结论血清IL-17A、TGF-β对高级别CIN患者术后复发具有一定预测价值,联合预测优于单独预测。 |
| 英文摘要: |
| AimTo analyze the predictive value of serum interleukin(IL) -17A and transforming growth factor-β (TGF-β) for postoperative recurrence in high-grade cervical intraepithelial neoplasia (CIN) patients. Methods223 high-grade CIN patients who underwent cervical conization were selected, followed up for 1 year, and divided into recurrent group and non-recurrent group according to the recurrence situation. Multivariate Logistic regression analysis was used to analyze serum IL-17 A, TGF-β levels and postoperative recurrence in patients with high-grade CIN. ROC curve was analyzed the value of IL-17 A and TGF-β in predicting postoperative recurrence in patients with high-grade CIN. Index joint predictive value was analyzed by decision curve. ResultsThe serum levels of IL-17A and TGF-β in the recurrent group were higher than those in the non-recurrent group (P＜0.05). The regression analysis results showed that high levels of IL-17A and TGF-β in preoperative serum was a risk factor for postoperative recurrence (P＜0.05). The ROC curve showed that the AUC of preoperative serum IL-17A and TGF-β predicting postoperative recurrence risk was ＞0.80. The decision curve showed that joint prediction was superior to individual prediction. ConclusionSerum IL-17A and TGF-β have certain predictive value for postoperative recurrence in high-grade CIN patients, and combined prediction is better than single prediction. |
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