| 浦柳美,黄国兰,潘天宇,宋瑞红.甲磺酸奥希替尼治疗晚期非小细胞肺癌的效果及预后相关因素分析.[J].中南医学科学杂志.,2023,(3):376-379. |
| 甲磺酸奥希替尼治疗晚期非小细胞肺癌的效果及预后相关因素分析 |
| Effect and prognostic factors of oxitinib mesylate in treatment of advanced non-small cell lung cancer |
| 投稿时间：2022-02-11 修订日期：2023-03-15 |
| DOI：10.15972/j.cnki.43-1509/r.2023.03.014 |
| 中文关键词: 甲磺酸奥希替尼 晚期非小细胞肺癌 治疗效果 预后相关因素 [ |
| 英文关键词:oxitinib mesylate advanced non-small cell lung cancer therapeutic effect prognostic factors |
| 基金项目:上海奉贤区科委社会类科技发展基金项目计划(20191230) |
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| 中文摘要: |
| 目的研究甲磺酸奥希替尼治疗晚期非小细胞肺癌(NSCLC)的临床效果,并探讨影响患者预后的相关因素。 方法选取NSCLC晚期患者142例,随机均分为两组,对照组给与常规培美曲塞二钠+顺铂(PC)化疗,观察组给与PC化疗加甲磺酸奥希替尼治疗。比较两组治疗效果和血清癌胚抗原(CEA)、血管内皮生长因子(VEGF)水平,分析影响患者预后的相关因素。 结果治疗后两组CEA、VEGF水平均降低,且观察组低于对照组(P＜0.05)。随访24个月,观察组总生存期、客观缓解率、疾病控制率均高于对照组(P＜0.05)。多因素Cox回归分析显示,吸烟、卡氏评分(KPS)、TNM分期、化疗方案是影响晚期NSCLC预后的危险因素。 结论甲磺酸奥希替尼治疗NSCLC晚期患者疗效明显。吸烟、KPS、TNM分期、化疗方案是影响晚期NSCLC预后的危险因素,应引起重视。 |
| 英文摘要: |
| AimTo study the clinical effect of oxitinib mesylate in the treatment of advanced non-small cell lung cancer (NSCLC), and to explore the related factors affecting the prognosis of patients. Methods142 patients with advanced NSCLC were randomly divided into two groups. The control group was given routine pemetrexed disodium plus cisplatin (PC) chemotherapy, and the observation group was given PC chemotherapy plus oxitinib mesylate. The therapeutic effect, serum carcinoembryonic antigen (CEA) and vascular endothelial growth factor (VEGF) levels of the two groups were compared, and the related factors affecting the prognosis of patients were analyzed. ResultsAfter treatment, the levels of CEA and VEGF in both groups decreased, and the observation group was lower than the control group (P＜0.05). After a follow-up of 24 months, the total survival time, objective response rate, and disease control rate of the obseruation group were higher than those of the control group (P＜0.05). Multivariate Cox regression analysis showed that smoking, KPS, TNM staging, and chemotherapy regimen were risk factors affecting the prognosis of advanced NSCLC. ConclusionsOxetinib mesylate has a significant therapeutic effect on advanced NSCLC patients.Smoking, KPS, TNM staging, and chemotherapy regimen are risk factors that affect the prognosis of advanced NSCLC and should be taken seriously. |
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