| 李程悦,苏泽红,肖李,龚慧芳,李富裕,练高建.Th17细胞分化调控及其治疗自身免疫性疾病的研究进展.[J].中南医学科学杂志.,2023,(2):305-308. |
| Th17细胞分化调控及其治疗自身免疫性疾病的研究进展 |
| Modulation of Th17 cell differentiation and its research progress in the treatment of autoimmune diseases |
| 投稿时间：2022-09-17 修订日期：2023-02-23 |
| DOI：10.15972/j.cnki.43-1509/r.2023.02.038 |
| 中文关键词: 自身免疫性疾病 辅助性T细胞17 白细胞介素-17 RORγt STAT3 [ |
| 英文关键词:autoimmune disease Th17 IL-17 RORγt STAT3 |
| 基金项目:湖南省自然科学基金面上项目(2019JJ40243)；湖南省教育厅生态环境与人类重大疾病防治重点实验室支持(20K107)；湖南省大学生创新创业训练计划(S202110555299) |
|
| 摘要点击次数: 120 |
| 全文下载次数: 1518 |
| 中文摘要: |
| 辅助性T细胞17(Th17)作为CD4＋T细胞的一个亚群,对包括自身免疫性疾病在内的某些炎性疾病的发生和发展起着重要作用。越来越多证据显示,在多种自身免疫性疾病患者血液中,Th17细胞数量及其相关细胞因子明显上升,靶向Th17细胞分化可能成为一种新的自身免疫性疾病临床治疗方案。本文讨论了Th17细胞与自身免疫性疾病的关系,并总结了调控Th17细胞分化的几个重要因素,以及一些以Th17细胞分化为靶点的自身免疫性疾病的治疗新策略。 |
| 英文摘要: |
| AimAs a subset of CD4+T cells, helper T cell 17(Th17) plays an important role in the occurrence and development of some inflammatory diseases, including autoimmune diseases. Mounting evidence has revealed that the number of Th17 cells and their associated cytokines are increased in the blood of patients with a variety of autoimmune diseases and targeting Th17 cells differentiation may be a novel clinical therapeutic schedule for autoimmune diseases. In this review, we discuss the relationship of Th17 cells and autoimmune diseases and conclude several factors that modulate Th17 cells differentiation. In addition, several novel therapeutic strategies for autoimmune diseases based on targeting at Th17 cells differentiation are reviewed. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|