| 杨思伟,袁圆,宋训君.RDW、PDW与su-PAR对重度创伤性颅脑损伤患者预后的评估价值.[J].中南医学科学杂志.,2023,(2):292-294, 298. |
| RDW、PDW与su-PAR对重度创伤性颅脑损伤患者预后的评估价值 |
| Prognostic value of RDW, PDW and su-PAR in the assessment of patients with severe traumatic brain injury |
| 投稿时间：2022-06-20 修订日期：2022-02-21 |
| DOI：10.15972/j.cnki.43-1509/r.2023.02.034 |
| 中文关键词: RDW PDW su-PAR 重度创伤性颅脑损伤 预后 [ |
| 英文关键词:RDW PDW su-PAR severe traumatic brain injury prognosis |
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| 中文摘要: |
| 目的研究红细胞体积分布宽度(RDW)、血小板体积分布宽度(PDW)、可溶性尿激酶型纤溶酶原激活物受体(su-PAR)对重度创伤性颅脑损伤(TBI)患者预后的评估价值。 方法120例TBI患者根据格拉斯哥昏迷评分(GCS)分为重度组64例、轻中度组56例,另选50例健康者为对照组。比较各组血清RDW、PDW及su-PAR水平,ROC曲线分析其在预测重度TBI患者预后中的价值。 结果重度组相较于轻中度组和对照组,RDW和PDW水平均升高,三组su-PAR依次下降(P＜0.05)。随访3个月,重度组预后不良33例,预后不良组RDW、PDW及su-PAR均高于预后良好组(P＜0.05)。重度组RDW、PDW、su-PAR与入院时GCS评分呈负相关(P＜0.05),su-PAR与RDW和PDW呈正相关(P＜0.05)。ROC曲线分析发现,三指标联合预测重度TBI患者预后不良的价值最高。 结论重度TBI患者RDW、PDW及su-PAR均异常升高,可作为评估TBI病情及预后的潜在指标。 |
| 英文摘要: |
| AimTo study the prognostic value of red cell volume distribution width (RDW), platelet volume distribution width (PDW) and soluble urokinase plasminogen activator receptor (su-PAR) in the assessment of patients with severe traumatic brain injury (TBI). Methods120 TBI patients were divided into severe group (64 cases) and mild-moderate group (56 cases) according to Glasgow coma scale (GCS), and 50 healthy individuals were as control group. The levels of serum RDW, PDW and su-PAR were compared among the groups. To evaluate the predictive value of the ROC curve on the prognosis of patients with severe TBI. ResultsCompared with mild-moderate group and control group, the levels of RDW and PDW in severe group increased, while su-PAR in three groups decreased in turn (P＜0.05). All patients were followed up for 3 months. 33 cases in the severe group had a poor prognosis. The RDW, PDW and su-PAR levels in the poor prognosis group were higher than in the good prognosis group (P＜0.05). The RDW, PDW and su-PAR in severe group were negatively correlated with GCS score at admission (P＜0.05), and su-PAR was positively correlated with RDW and PDW (P＜0.05). ROC curve suggested that the combination of the three indicatorshad the highest value in predicting poor prognosis in patients with severe TBI. ConclusionThe levels of RDW, PDW and su-PAR in patients with severe TBI were abnormally elevated, which can be used as a potential indicator to evaluate the condition and prognosis of TBI patients. |
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