| 孔德娜,宋乐,沈贵月.Th17/Treg平衡对慢性丙型肝炎病毒感染患者抗病毒治疗的指导价值.[J].中南医学科学杂志.,2023,(2):273-276. |
| Th17/Treg平衡对慢性丙型肝炎病毒感染患者抗病毒治疗的指导价值 |
| The guiding value of Th17/Treg balance for antiviral therapy in patients with chronic hepatitis C virus infection |
| 投稿时间：2022-07-08 修订日期：2022-11-28 |
| DOI：10.15972/j.cnki.43-1509/r.2023.02.029 |
| 中文关键词: 丙型肝炎病毒 Th17 Treg Th17/Treg 抗病毒治疗 [ |
| 英文关键词:hepatitis C virus Th17 Treg Th17/Treg antiviral therapy |
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| 中文摘要: |
| 目的探究辅助性T细胞/调节性T细胞(Th17/Treg)平衡对慢性丙型肝炎病毒感染患者抗病毒治疗的指导价值。 方法选取慢性丙型肝炎病毒(HCV)感染患者100例为研究对象,根据随访12个月HCV-RNA阳性情况将其分为阳性组59例及阴性组41例,另选同期体检健康者30例为对照组。HCV感染患者均采用常规口服索磷布韦维帕他韦片,连续治疗12周。比较各组入院治疗前、治疗后血清HCV-RNA、肝功能、Th17、Treg细胞百分比和Th17/Treg。随访12个月,观察HCV感染患者预后不良的发生情况。 结果治疗后,阳性组Treg细胞百分比、谷丙转氨酶(GPT)、谷草转氨酶(GOT)、总胆红素(TBIL)水平及HCV-RNA定量均高于阴性组,GPT、GOT、TBIL水平均高于对照组,Treg细胞百分比低于对照组,Th17细胞百分比低于阴性组及对照组,Th17/Treg比值高于对照组(P＜0.05)。Th17、Treg细胞百分比及Th17/Treg与HCV-RNA定量均呈正相关(r=0.416、0.356、0.327,P＜0.05)；Th17细胞ROC曲线下面积(AUC)为0.796,灵敏度为0.797,特异度为0.854；Treg细胞AUC为0.886,灵敏度为0.949,特异度为0.805；Th17/Treg比值AUC为0.681,灵敏度为0.763,特异度为0.537。 结论外周血Th17、Treg细胞百分比及Th17/Treg比值有助于临床对HCV感染患者HCV-RNA阳性进行早期预测,可为后续抗病毒治疗提供指导。 |
| 英文摘要: |
| AimTo explore the guiding value of helper T cell/regulatory T cell (Th17/Treg) balance for antiviral treatment of patients with chronic hepatitis C virus infection. MethodsA total of 100 patients with chronic hepatitis C virus (HCV) infection were selected as the research objects, and the patients were grouped into groups according to their prognosis status (HCV-RNA negative to positive) after a 12-month follow-up 59 cases in the positive group and 41 cases in the negative group, 30 cases who underwent routine physical examination in our hospital during the same period were selected as the control group. All patients in the group were treated with conventional oral Sofosbuvir velpatasvir tablets for 12 weeks of continuous basic treatment. The fasting venous blood was collected before admission and 48 weeks after treatment to detect serum HCV-RNA, liver function, Th17 and Treg cell percentages, and calculate the Th17/Treg ratio. The patients were followed up for 12 months to observe the occurrence of poor prognosis. ResultsAfter treatment, the percentage of Treg cells, the levels of glutamic pyruvic transaminase (GPT), glutamic-oxalacetic transaminase (GOT), total bilirubin (TBIL) and HCV-RNA in the positive group were higher than those in the negative group, the levels of GPT, GOT and TBIL were higher than those in the control group, the percentage of Treg cells was lower than that in the control group, the percentage of Th17 cells was lower than that in the negative group and the control group, and the ratio of Th17 / Treg was higher than that in the control group (P＜0.05); The percentage of Th17 and Treg cells and Th17/Treg and HCV-RNA quantification are positively correlated (r=0.416,0.356,0.327, P＜0.05); Th17 cells' area under the curve (AUC)=0.796, sensitivity is 0.797, specificity 0.854; Treg cell AUC=0.886, sensitivity 0.949, specificity 0.805; Th17/Treg ratio AUC=0.681, sensitivity 0.763, specificity 0.537. ConclusionTesting peripheral hematoma Th17, Treg cell percentage and Th17/Treg ratio of patients can help clinical diagnosis of early prognosis of patients with HCV infection and provide guidance for subsequent antiviral treatment. |
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