| 张振学,王佳慧.认知矫正联合常规药物治疗双相情感障碍患者疗效及对TBIL、UA和BDNF的影响.[J].中南医学科学杂志.,2023,(2):246-249. |
| 认知矫正联合常规药物治疗双相情感障碍患者疗效及对TBIL、UA和BDNF的影响 |
| Effect of cognitive correction combined with conventional drugs on patients with bipolar disorder and its effect on TBIL, UA and BDNF |
| 投稿时间：2021-11-03 修订日期：2022-05-23 |
| DOI：10.15972/j.cnki.43-1509/r.2023.02.022 |
| 中文关键词: ]认知矫正 药物治疗 双相情感障碍 神经营养因子 总胆红素 尿酸 [ |
| 英文关键词:cognitive correction medication bipolar disorder neurotrophic factor total bilirubin uric acid |
| 基金项目:安徽省卫生健康委科研项目(AHWJ2021a035) |
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| 中文摘要: |
| 目的研究认知矫正联合常规药物治疗双相情感障碍患者疗效及对脑源性神经营养因子(BDNF)、总胆红素(TBIL)、尿酸(UA)水平的影响。 方法选取106例双相情感障碍患者分为常规组(n＝53)和联合组(n＝53)。常规组给予常规药物治疗,联合组给予认知矫正联合常规药物治疗。比较两组治疗总有效率、TBIL、UA、BDNF、认知评价、临床疾病严重度量表-双相情感障碍版(CGI-BP)评分、汉密尔顿抑郁量表(HAMD)评分及躁狂量表(BRMS)评分。 结果联合组治疗总有效率高于常规组(P＜0.05)。与治疗前比较,治疗后两组BDNF、TBI水平均升高,UA、CGI-BP评分、HAMD评分及BRMS评分均降低,且联合组改善较常规组更为显著(P＜0.05)；治疗后,联合组视觉再生图像b、图像c、视觉再生总分、威斯康星卡片分类测试(WCST)分数类、数字符号得分均升高,连线测试A、连线测试B、WCST错误数、持续错误数等得分均降低,且联合组治疗后较常规组治疗后改善更为显著(P＜0.05)。 结论认知矫正联合常规药物治疗双相情感障碍可提升治疗效果,改善临床症状,提高神经认知功能,具有较高临床价值。 [ |
| 英文摘要: |
| AimTo study the efficacy of cognitive correction combined with conventional drugs in the treatment of bipolar disorder and its effect on the levels of brain-derived neurotrophic factor (BDNF), total bilirubin (TBIL) and uric acid (UA). Methods106 patients with bipolar disorder were divided into routine group (n＝53) and combined group (n＝53). The routine group was given routine drug treatment, and the combined group was given cognitive correction combined with routine drug treatment. The treatment efficiency, TBIL, UA, BDNF, cognitive evaluation, clinical global impression-bipolar disorder (CGI-BP) score, Hamilton depression scale (HAMD) score and Beck Ravensen mania scale (BRMS) score were compared between the two groups. ResultsThe effective rate of the combined group was higher than that of the routine group (P＜0.05). After treatment, the levels of BDNF and TBI increased, and the scores of UA, CGI-BP, HAMD and BRMS decreased in the two groups, and the improvement in the combined group was more significant than that in the conventional group (P＜0.05); After treatment, the scores of visual regeneration image B, image C, visual regeneration, Wisconsin card sorting test (WCST) and digital symbols in the combined group increased, and the scores of connection test a, connection test B, WCST errors and continuous errors in the combined group decreased, and the improvement in the combined group was more significant than that in the conventional group (P＜0.05). ConclusionCognitive correction combined with conventional drugs in the treatment of bipolar disorder can improve the treatment effect, improve clinical symptoms and improve neurocognitive function, which has high clinical value. |
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