| 曹昌德,余万庆,童庆好,姚伟,陈亚婷.抑郁障碍患者外周血T淋巴细胞及其亚群线粒体损伤的临床意义.[J].中南医学科学杂志.,2023,(1):117-119. |
| 抑郁障碍患者外周血T淋巴细胞及其亚群线粒体损伤的临床意义 |
| Clinical significance of peripheral blood T lymphocytes and mitochondrial damage of subsets in patients with depressive disorder |
| 投稿时间：2022-03-14 修订日期：2022-06-10 |
| DOI：10.15972/j.cnki.43-1509/r.2023.01.031 |
| 中文关键词: 抑郁障碍 T淋巴细胞 亚群线粒体损伤 免疫失衡 [ |
| 英文关键词:depressive disorder T lymphocytes mitochondrial damage immune imbalance |
| 基金项目:安徽省高校自然科学研究项目(KJ2021A1370) |
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| 中文摘要: |
| 目的探究抑郁障碍患者外周血T淋巴细胞及其亚群线粒体损伤检测及其意义。 方法收集72例抑郁障碍患者为观察组,另选取51名同期体检正常者为对照组,采用流式细胞术测定所有受试者外周血T淋巴细胞亚群水平和T淋巴细胞亚群线粒体功能损伤情况,并分析其临床意义。 结果观察组抑郁自评量表(SDS)评分高于对照组(P＜0.05)；观察组CD3＋、CD4＋、CD45＋及CD4＋/CD8＋水平均低于对照组(P＜0.05),CD8＋水平高于对照组(P＜0.05)；不同类型抑郁障碍患者CD4＋差异有显著性(P＜0.05)；Pearson相关检验结果显示,抑郁障碍患者SDS评分与T淋巴细胞亚群CD3＋、CD4＋、CD45＋水平均呈负相关(r＝－0.233,－0.436,－0.347,P＜0.05),与CD8＋水平呈正相关(r＝0.496,P＜0.05)。两组抑制性T细胞(Ts)线粒体损伤比较,差异有显著性(P＜0.05)。 结论抑郁障碍患者T淋巴细胞及其亚群表达存在一定程度的免疫失衡,部分患者出现T淋巴细胞线粒体损伤。 |
| 英文摘要: |
| AimTo explore the detection and significance of mitochondrial damage in peripheral blood T lymphocytes and their subsets in patients with depressive disorder. Methods72 patients with depressive disorder were collected as study group, and another 51 subjects who underwent physical examination at the same time were selected as control group. Flow cytometry was used to determine the levels of peripheral blood T lymphocyte subsets and the mitochondrial function damage of T lymphocyte subsets, and the clinical significance was analyzed. ResultsThe self-rating depression scale (SDS) score of study group was higher than that of control group (P＜0.05). The levels of CD3＋, CD4＋, CD45＋ and CD4＋/CD8＋ in the observation group were lower than those in the control group (P＜0.05), and the levels of CD8＋ were higher than those in the control group (P＜0.05). CD4＋ level of patients with different types of depression was significantly different (P＜0. 05). Pearson correlation test showed that the SDS score of patients with depressive disorder was negatively correlated with the levels of T lymphocyte subsets CD3＋, CD4＋ and CD45＋ (r＝－0.233, －0.436, －0.347, P＜0.05), and was positively correlated with CD8＋ (r＝0.496, P＜0.05). The difference in TS mitochondrial damage was statistically significant between the two groups (P＜0.05). ConclusionThere is a certain degree of immune imbalance in the expressions of T lymphocytes and their subsets in patients with depressive disorder, and some patients have mitochondrial damage of T lymphocytes. |
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