| 李剑侠,林小祥,余勇波,黄先锋.小动脉硬化脑血管病危险因素分析及sTM、CD62P、VE-cadherin对其预后的预测.[J].中南医学科学杂志.,2023,(1):83-86. |
| 小动脉硬化脑血管病危险因素分析及sTM、CD62P、VE-cadherin对其预后的预测 |
| Analysis of risk factors of arteriosclerotic cerebrovascular disease and prediction of prognosis by STM, CD62P and VE-cadherin |
| 投稿时间：2022-02-28 修订日期：2022-06-21 |
| DOI：10.15972/j.cnki.43-1509/r.2023.01.021 |
| 中文关键词: sTM CD62P VE-cadherin 小动脉硬化脑血管病 危险因素 预后 [ |
| 英文关键词:sTM CD62P VE-cadherin arteriole sclerosis and cerebrovascular disease risk factors prognosis |
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| 中文摘要: |
| 目的分析小动脉硬化脑血管病的危险因素,及可溶性血栓调节蛋白(sTM)、P选择素(CD62P)、钙黏蛋白(VE-cadherin)对其预后的预测价值。 方法选择小动脉硬化脑血管病患者180例为观察组,根据预后分为预后不良组和预后良好组,另设50例健康者为对照组。检测各组血清sTM、VE-cadherin、CD62P血小板水平,分析其与预后的相关性,以及三者联合检测对预后的评估价值,分析小动脉硬化脑血管病的危险因素。 结果sTM、VE-cadherin、CD62P血小板水平观察组高于对照组,预后不良组高于预后良好组(P＜0.05)。sTM、VE-cadherin、CD62P血小板水平与预后呈正相关(P＜0.05)；三者联合检测对预后的诊断效能高于单独检测(P＜0.05)。sTM、VE-cadherin、CD62P血小板水平是小动脉硬化脑血管病的危险因素(P＜0.05)。 结论sTM、VE-cadherin、CD62P是小动脉硬化脑血管病的危险因素,三者联合应用对其预后的预测价值较高。 |
| 英文摘要: |
| AimTo analyze the risk factors of small arteriosclerotic cerebrovascular disease and the predictive value of soluble thrombomodulin (sTM), P-selectin (CD62P) and cadherin (VE-cadherin) on its prognosis. Methods180 patients with smallarteriosclerosis and cerebrovascular disease were selected as the observation group. According to the prognosis, they were divided into the poor prognosis group and the good prognosis group. Another 50 healthy people were selected as the control group. Serum sTM, VE-cadherin and CD62P platelets levels were detectedin each group,and their correlation with prognosis was analyzed, as well as the evaluation value of the three combined detection on prognosis, and the risk factors of small arteriosclerosis cerebrovascular disease were analyzed. ResultsThe platelet levels of sTM, VE-cadherin and CD62P in the observation group were higher than those in the control group,and those in the poor prognosis group were higher than those in the good prognosis group(P＜0.05). The platelet levels of sTM, VE-cadherin and CD62P were positively correlated with prognosis(P＜0.05); The diagnostic efficacy of the three combined tests was higher than that of the single test(P＜0.05). sTM, VE-cadherin and CD62P platelets were risk factors of arteriosclerotic cerebrovascular disease(P＜0.05). ConclusionsTM, VE-cadherin and CD62P are risk factors of arteriosclerotic cerebrovascular disease, and the combined application has high predictive value for its prognosis. |
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