| 陈雪猛,王勇,吴维.基于网络药理学分析桂枝治疗类风湿关节炎的作用机制.[J].中南医学科学杂志.,2023,(1):45-48. |
| 基于网络药理学分析桂枝治疗类风湿关节炎的作用机制 |
| Mechanism of cassia twig in treating rheumatoid arthritis based on network pharmacology |
| 投稿时间：2022-06-15 修订日期：2022-11-30 |
| DOI：10.15972/j.cnki.43-1509/r.2023.01.011 |
| 中文关键词: 桂枝 类风湿关节炎 网络药理学 [ |
| 英文关键词:cassia twig rheumatoid arthritis pharmacology of network |
| 基金项目:重庆市中医药科研项目(2023MSXM182) |
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| 中文摘要: |
| 目的基于网络药理学分析桂枝治疗类风湿关节炎的作用机制。 方法采用GeneCards数据库获取类风湿关节炎的靶点,中药靶点采用中药系统药理学分析平台(TCMSP),依据OB≥30%,DL≥0.18为桂枝活性成分的筛选条件,获取相应靶点信息。将类风湿关节炎的疾病靶点和桂枝的靶点做交集分析,将得到的共同靶点进行蛋白PPI互作分析,利用DAVID数据库分析靶点的GO基因功能和富集通路。 结果TCMSP数据库共筛选出桂枝48个靶点。进行交集分析,共得到30个共同靶点；共同靶点PPI蛋白互作网络图显示,关键靶点之间联系密切；基因富集分析显示,30个共同靶点与146个基因功能相关,与56条信号通路相关。 结论本研究通过网络药理学发现,桂枝能作用于BAX、CASP3、CASP8、CASP9、TGFB1、JUN和PIK3CG,通过TNF通路,抑制炎症反应发挥其抗炎活性。 |
| 英文摘要: |
| AimTo analyze the mechanism of cassia twig in the treatment of rheumatoid arthritis based on network pharmacology. MethodsThe GeneCards database was used to obtain the target points of rheumatoid arthritis, and the target of traditional Chinese medicine was obtained by TCM Systematic Pharmacological analysis platform (TCMSP), and the information of corresponding target was obtained according to OB≥30%, DL≥0.18 as the screening conditions for active components of cassia twig. The intersection analysis of the disease targets of rheumatoid arthritis and the targets of cassia twig was performed, and the obtained common targets were analyzed for protein PPI interaction. The DAVID database was used to analyze the GO gene function and enrichment pathway of the targets. ResultsA total of 48 targets of cassia twig were screened out in TCMSP database. 30 common targets were obtained by intersection analysis. Common target PPI protein interaction network diagram showed that the key targets were closely related. Gene enrichment analysis showed that 30 common targets were associated with 146 gene functions and 56 signaling pathways. ConclusionThrough network pharmacology, it was found in this study that cassia chinensis acts on BAX, CASP3, CASP8, CASP9, TGFB1, JUN and PIK3CG, and exerts its anti-inflammatory activity through TNF pathway, inhibiting inflammatory response. |
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