龙思鸿,谢群,孙珊珊,曹琴,曾汇文,贺莉萍.艰难梭菌毒素及其检测方法研究进展.[J].中南医学科学杂志.,2022,(6):941-944.
艰难梭菌毒素及其检测方法研究进展
Research progress of Clostridium difficile toxin and its detection methods
投稿时间:2022-08-10  修订日期:2022-10-15
DOI:10.15972/j.cnki.43-1509/r.2022.06.041
中文关键词:  艰难梭菌毒素  艰难梭菌感染  检测方法 [
英文关键词:Clostridium difficile  Clostridium difficile infection  detection method
基金项目:湖南省大学生创新创业训练计划项目(湘教通[2021]197号No.3676);传染病预防控制国家重点实验室自主研究开放课题(2021SKLID302) 作者简介:龙思鸿,研究方向为传染性疾病预防与控制,E-mail为1049155614@qq.com。通信作者曾汇文,硕士,助理实验师,研究方向为卫生微生物检测与疾病预防,E-mail为992146082@qq.com。通信作者贺莉萍,博士,教授,硕士研究生导师,研究方向为分子流行病学、现场流行病学,E-mail为290525442@qq.com。
作者单位E-mail
龙思鸿 湘南学院公共卫生学院,湖南省郴州市 423099 e-mail为1049155614@qq.com,e-mail为992146082@qq.com,e-mail为290525442@qq.com 
谢群 湘南学院公共卫生学院,湖南省郴州市 423099  
孙珊珊 湘南学院公共卫生学院,湖南省郴州市 423099  
曹琴 湘南学院公共卫生学院,湖南省郴州市 423099  
曾汇文 湘南学院公共卫生学院,湖南省郴州市 423099 e-mail为1049155614@qq.com,e-mail为992146082@qq.com,e-mail为290525442@qq.com 
贺莉萍 湘南学院公共卫生学院,湖南省郴州市 423099 e-mail为1049155614@qq.com,e-mail为992146082@qq.com,e-mail为290525442@qq.com 
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中文摘要:
      ]艰难梭菌是医院感染性腹泻的主要病原菌。艰难梭菌感染严格依赖于艰难梭菌产生的蛋白质毒素。近年来对艰难梭菌毒素的进一步研究有了新的发现,也发展和建立了一些新的艰难梭菌毒素检测方法。本文对艰难梭菌毒素的生物学和艰难梭菌毒素及其基因检测方法的研究进展做一综述,旨在为艰难梭菌感染防治提供参考。
英文摘要:
      Clostridium difficile (C.difficile) is the main pathogen of nosocomial infectious diarrhea. C.difficile infection is strictly dependent on the protein toxins produced by C.difficile. In recent years, there have been new discoveries in the further study of Clostridium difficile toxin, and some new methods for detecting Clostridium difficile toxin have also been developed and established. In this paper, the biology of Clostridium difficile toxin and the research progress of Clostridium difficile toxin and its genetic detection methods are reviewed, which in order toprovides a reference for the prevention and treatment of Clostridium difficile infection.
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