| 贾连群,邰贺,吕美君.基于线粒体功能障碍探讨补肾健脾化湿法对PCOS-IR作用的研究进展.[J].中南医学科学杂志.,2022,(6):937-940. |
| 基于线粒体功能障碍探讨补肾健脾化湿法对PCOS-IR作用的研究进展 |
| Research progress on the mechanism of “tonifying the kidney, strengthening the spleen and removing dampness” on PCOS-IR based on mitochondrial dysfunction |
| 投稿时间：2021-06-18 修订日期：2021-12-27 |
| DOI：10.15972/j.cnki.43-1509/r.2022.06.040 |
| 中文关键词: 补肾健脾化湿法 PCOS IR 线粒体 [ |
| 英文关键词:tonifying the kidney, strengthening the spleen and removing dampness PCOS IR mitochondria |
| 基金项目:国家自然科学基金面上项目(82074145)；辽宁省“兴辽英才计划”项目(XLYC1902100)；辽宁省高校黄大年式教师团队(辽教涵[2020]426号) 作者简介:贾连群,博士,教授,博士研究生导师,研究方向为中西医结合防治代谢性疾病基础与临床的研究,E-mail为Jlq-8@163.com。 |
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| 中文摘要: |
| 多囊卵巢综合征(PCOS)是常见的妇科内分泌疾病,常伴随胰岛素抵抗(IR)。中医理论认为PCOS-IR发病主要与脾肾密切相关,肾亏脾虚、痰湿内蕴是PCOS-IR的基本病机,补肾健脾化湿法是治疗PCOS-IR的重要方法。研究显示线粒体功能异常与PCOS-IR发病密切相关。本文在中医理论指导下,以线粒体功能异常为靶点,探讨补肾健脾化湿法对PCOS-IR的防治作用。 |
| 英文摘要: |
| Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease, often accompanied by insulin resistance (IR). TCM theory holds that the pathogenesis of PCOS-IR is mainly closely related to the spleen and kidney. Kidney deficiency, spleen deficiency and phlegm-dampness are the basic pathogenesis of PCOS-IR and the principle of tonifying kidney, strengthening spleen and removing dampness is an important method to treat PCOS-IR. Studies have shown that mitochondrial dysfunction is closely related to the pathogenesis of PCOS-IR. Under the guidance of traditional Chinese medicine theory, with mitochondrial dysfunction as the target, discusses the prevention and treatment effect of tonifying kidney and invigorating spleen and humidifying method on PCOS-IR. |
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