| 陈少鹏,李秀芩,邵伟华,姚丽霞,李芳,李绍冰.老年慢性心力衰竭患者血浆miR-423-5p、miR-499-5p、miR-210-3p水平与其营养状况和睡眠质量的相关性.[J].中南医学科学杂志.,2022,(6):869-872. |
| 老年慢性心力衰竭患者血浆miR-423-5p、miR-499-5p、miR-210-3p水平与其营养状况和睡眠质量的相关性 |
| Correlation of plasma miR-423-5p, miR-499-5p, miR-210-3p levels with nutritional status and sleep quality in elderly patients with chronic heart failure |
| 投稿时间：2022-06-29 修订日期：2022-09-30 |
| DOI：10.15972/j.cnki.43-1509/r.2022.06.021 |
| 中文关键词: 老年慢性心力衰竭 miR-423-5p miR-499-5p miR-210-3p 营养状况 睡眠质量 [ |
| 英文关键词:senile chronic heart failure miR-423-5p miR-499-5p miR-210-3p nutritional status sleep quality |
| 基金项目:河北省卫生计生委医学科学研究重点课题(20170027；20170263) 作者简介:陈少鹏,硕士,主治医师,研究方向为老年慢性疾病预防与管理,E-mail为xiuqinli2019@163.com。通信作者李绍冰,博士,主任医师,研究方向为老年心血管病的诊断与治疗,E-mail为348500124@qq.com。 |
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| 中文摘要: |
| 目的探究老年慢性心力衰竭(CHF)患者血浆miR-423-5p、miR-499-5p及miR-210-3p水平与其营养状况和睡眠质量的相关性。 方法采用微型营养评价量表(MNA)与匹兹堡睡眠质量指数量表(PSQI)评估106例CHF患者营养状况及睡眠质量；将患者按不同MNA、PSQI和心功能分组,比较各组血浆miR-423-5p、miR-499-5p及miR-210-3p水平,并分析其相关性。 结果随着心功能分级的增加,miR-423-5p、miR-499-5p及miR-210-3p水平逐渐增加,MNA评分逐渐减少,PSQI评分逐渐增加。miR-423-5p、miR-499-5p及miR-210-3p水平互呈正相关；miR-423-5p、miR-499-5p及miR-210-3p水平与营养状况呈负相关；miR-423-5p、miR-499-5p与睡眠质量呈正相关(P＜0.05)。 结论血浆miR-423-5p、miR-499-5p及miR-210-3p水平与CHF患者心力衰竭程度、营养状况和睡眠质量密切相关。 |
| 英文摘要: |
| To investigate the correlation plasma of miR-423-5p, miR-499-5p and miR-210-3p level with nutritional status and sleep quality in elderly patients with chronic heart failure (CHF). MethodsThe nutritional status and sleep quality of 106 hospitalized patients with CHF were evaluated by mini-Nutritional Assessment Scale (MNA) and Pittsburgh Sleep Quality Index (PSQI). The levels of miR-423-5p, miR-499-5p and miR-210-3p in plasma were detected, and their correlation were analyzed. ResultsWith the increase of cardiac function grade, the plasma levels of miR-423-5p, miR-499-5p and miR-210-3p gradually increased, the MNA score gradually decreased, and the PSQI score gradually increased. The levels of miR-423-5p, miR-499-5p and miR-210-3p were positively correlated with each other; The levels of miR-423-5p, miR-499-5p, miR-210-3p were negatively correlated with their nutritional status; miR-423-5p, miR-499-5p were positively correlated with sleep quality (P＜0.05). ConclusionPlasma levels of miR-423-5p, miR-499-5p and miR-210-3p are closely related to the degree of heart failure, nutritional status and sleep quality of CHF patients. |
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