熊丽,邹洁宁,王瑞玲,肖进蕾,陈丹丹,张慧.枸橼酸氯米芬联合HCG治疗对PCOS患者AMH水平和排卵率的影响.[J].中南医学科学杂志.,2022,(4):572-575.
枸橼酸氯米芬联合HCG治疗对PCOS患者AMH水平和排卵率的影响
Effect of clomiphene citrate capsule combined with HCG treatment on AMH levels and ovulation rate in patients with PCOS
投稿时间:2021-05-24  修订日期:2021-10-29
DOI:10.15972/j.cnki.43-1509/r.2022.04.027
中文关键词:  枸橼酸氯米芬  人绒毛膜促性腺激素  多囊卵巢综合征  抗缪勒氏管激素  排卵率
英文关键词:clomiphene citrate  HCG  PCOS  AMH  ovulation rate
基金项目:
作者单位E-mail
熊丽 武汉市武昌医院妇产科,湖北省武汉市430063 e-mail为xiongxiong7273@163.com,e-mail为zhanghui@163.com 
邹洁宁 武汉市武昌医院妇产科,湖北省武汉市430063  
王瑞玲 武汉市武昌医院妇产科,湖北省武汉市430063  
肖进蕾 武汉市武昌医院妇产科,湖北省武汉市430063  
陈丹丹 武汉市武昌医院妇产科,湖北省武汉市430063  
张慧 武汉市武昌医院妇产科,湖北省武汉市430063 e-mail为xiongxiong7273@163.com,e-mail为zhanghui@163.com 
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中文摘要:
      目的探讨枸橼酸氯米芬联合人绒毛膜促性腺激素(HCG)治疗多囊卵巢综合征(PCOS)疗效及对患者抗缪勒氏管激素(AMH)水平和排卵率的影响。方法选取PCOS患者100例随机等分为对照组和联合组,对照组口服枸橼酸氯米芬胶囊,联合组在此基础上增加HCG干预。比较两组AMH、性激素结合球蛋白(SHBG)、胰岛素抵抗程度、性激素、排卵指标、妊娠指标和安全有效性。结果治疗后两组胰岛素、胰岛素抵抗指数、AMH、黄体生成素、卵泡刺激素不同程度降低,且联合组低于对照组(P<0.05)。治疗后两组SHBG、胰岛素分泌指数、孕酮、雌二醇不同程度升高,且联合组高于对照组(P<0.05)。治疗后联合组排卵率、妊娠率、治疗有效率均高于对照组(P<0.05)。两组不良反应比较差异无显著性(P>0.05)。结论枸橼酸氯米芬联合HCG治疗PCOS,可降低患者血清AMH调节性激素水平,改善卵巢功能,具有临床应用价值。
英文摘要:
      To explore the efficacy of clomiphene citrate combined with human chorionic gonadotropin (HCG) in the treatment of polycystic ovary syndrome (PCOS) and its effect on the anti-mullerian tube hormone (AMH) level and ovulation rate in patients. Methods100 cases of PCOS patients were selected and randomly divided into control group and combination group, 50 cases in each group. The control group was treated with clomiphene citrate capsule orally, and the observation group was additively treated with HCG intervention. The levels of anti-Muller's tube hormone (AMH), sex hormone binding globulin (SHBG), insulin resistance, serum sex hormone levels, ovulation and pregnancy indexes and safety and efficacy were compared between the two groups. ResultsAfter treatment, insulin, insulin resistance index, AMH, luteizing hormone and follicle stimulating were reduced to varying degrees, and the combination group was lower than the control group(P<0.05). After treatment, SHBG, insulin secretion index, progesterone and estradiol increased to different degrees, and the combination group was higher than the control group(P<0.05). The ovulation rate, pregnancy rate and treatment response rate of the combination group were higher than that of the control group(P<0.05). There was no significant difference of adverse reaction between the two groups(P>0.05). ConclusionClomiphene citrate combined with HCG for PCOS can reduce the serum regulating hormone level of AMH and improve ovarian function, which has clinical application value.
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