| 刘汉雄,杨小安,熊潭玮.乙型肝炎肝硬化患者内皮祖细胞数量、功能变化及与Child-Pugh评分的相关性.[J].中南医学科学杂志.,2022,(4):525-527, 535. |
| 乙型肝炎肝硬化患者内皮祖细胞数量、功能变化及与Child-Pugh评分的相关性 |
| Change of the number and functional activity of endothelial progenitor cell and their correlation with child-pugh score in hepatitis B virus-related cirrhosis patients |
| 投稿时间：2021-07-28 修订日期：2021-11-15 |
| DOI：10.15972/j.cnki.43-1509/r.2022.04.014 |
| 中文关键词: 乙型肝炎肝硬化 内皮祖细胞 Child-Pugh评分 |
| 英文关键词:hepatitis B cirrhosis endothelial progenitor cell Child-Pugh score |
| 基金项目:湖南省卫健委科技项目(202103030567) 作者简介:刘汉雄,硕士,副主任医师,研究方向为消化疾病及内镜技术,E-mail为lhx2000@eyou.com。通信作者熊潭玮,硕士,主治医师,研究方向为消化疾病及内镜技术,E-mail为526485545@qq.com。 |
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| 中文摘要: |
| 目的探讨乙型肝炎肝硬化患者循环内皮祖细胞(EPC)的数量、功能变化及与Child-Pugh评分的相关性。方法纳入乙型肝炎肝硬化患者60例,其中Child-Pugh A、B、C级各20例,另选20例健康体检者为对照组。计算患者Child-Pugh评分,采外周血分离提取EPC,检测EPC在体外的迁移、增殖能力。结果乙型肝炎肝硬化早期患者(Child-Pugh A、B级)循环EPC数量较对照组增加(P＜0.05),Child-Pugh C级患者循环EPC数量较对照组高但差异无显著性(P＞0.05)。乙型肝炎肝硬化患者循环EPC迁移、增殖能力均较对照组下降(P＜0.05),且与Child-Pugh评分呈负相关(P＜0.05)。结论乙型肝炎肝硬化患者EPC的动员能力增强,但EPC迁移、增殖能力减弱,可能与乙型肝炎肝硬化肝损伤程度相关。 |
| 英文摘要: |
| To investigate the change of the number and function of circualting endothelial progenitor cell (EPC) and its correlation with Child-Pugh scorein patients with hepatitis B cirrhosis. MethodsSixty patients with hepatitis B cirrhosis were enrolled, including 20 Child-Pugh A patients, 20 Child-Pugh B patients, and 20 Child-Pugh C grades. Another 20 healthy volunteers as the control group. Calculate Child-Pugh score, detect the migration and proliferation of EPC in vitro. ResultsThe number of circulating EPC in patients with early hepatitis B cirrhosis (Child-Pugh A, B) was significantly higher than that of the healthy control group(P＜0.05), and the number of circulating EPC in Child-Pugh C level patients was higher than that of the healthy control group, but there was no difference between the two groups(P＞0.05). The migration and proliferation of circulating EPC in patients with hepatitis B cirrhosis were significantly lower than those in healthy control group(P＜0.05), and they were negatively correlated with Child-Pugh score(P＜0.05). ConclusionThe mobilization ability of EPC in patients with hepatitis B cirrhosis is enhanced. But the migration and proliferation of EPC is weakened, which may be related to the severity of hepatitis B cirrhosis. |
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