| 黄文霞,李海涛,黄玉冰,廖旺.25(OH)D水平对高血压合并冠心病患者心肌重构及左心室舒张功能的影响.[J].中南医学科学杂志.,2022,(4):521-524. |
| 25(OH)D水平对高血压合并冠心病患者心肌重构及左心室舒张功能的影响 |
| Effect of 25(OH)D level on myocardial remodeling and diastolic function in patients with hypertension complicated with coronary heart disease |
| 投稿时间：2021-10-25 修订日期：2022-04-12 |
| DOI：10.15972/j.cnki.43-1509/r.2022.04.013 |
| 中文关键词: 25羟基维生素D 心肌重构 高血压 左心室舒张功能 冠心病 |
| 英文关键词:25(OH)D myocardial remodeling hypertension left ventricular diastolic function coronary heart disease |
| 基金项目:海南省自然科学基金项目(814319) 作者简介:黄文霞,硕士,主治医师,研究方向为高血压、心力衰竭与心肌病的诊治,E-mail为xiamihuangwenxia@126.com。通信作者廖旺,博士,主任医师,研究方向为动脉粥样硬化与冠心病的诊治,E-mail为crain-lw@163.com。 |
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| 中文摘要: |
| 目的分析25羟基维生素D[25(OH)D]水平对高血压合并冠心病患者心肌重构及左心室舒张功能的影响。方法选择80例高血压合并冠心病患者,根据左心室质量指数及左心室舒张功能分为心肌重构组和无心肌重构组、舒张功能障碍组和无舒张功能障碍组。Logistic回归分析影响高血压合并冠心病患者心肌重构及左心室舒张功能的独立危险因素,ROC曲线分析其诊断效能。结果与无心肌重构组比较,心肌重构组收缩压、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)升高,25(OH)D降低(P＜0.05)。与无舒张功能障碍组比较,舒张功能障碍组体质指数(BMI)、25(OH)D水平降低,LDLC升高(P＜0.05)。25(OH)D是患者心肌重构及左心室舒张功能的危险因素(P＜0.05)。25(OH)D水平对患者心肌重构、舒张功能障碍有较好的诊断效能。结论25(OH)D水平是影响高血压合并冠心病患者心肌重构及左心室舒张功能的独立危险因素,早期检测其水平有助于临床诊疗。 |
| 英文摘要: |
| To analyze the influence of 25-hydroxyvitamin D [25(OH)D] level on myocardial remodeling and left ventricular diastolic function in patients with hypertension complicated with coronary heart disease. Methods80 patients with hypertension complicated with coronary heart disease were collected and divided into myocardial remodeling group and no myocardial remodeling group, diastolic dysfunction group and non-diastolic dysfunction group according to left ventricular mass index and left ventricular diastolic function. The independent risk factors affecting cardiac remodeling and left ventricular diastolic function in patients were analyzed by Logistics regression, and the diagnostic efficacy was studied by ROC curve. ResultsCompared with no-myocardial remodeling group, the levels of systolic blood pressure, total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) in the muscle remodeling group increased and 25(OH)D decreased(P＜0.05). Compared with the non-diastolic dysfunction group, the levels of body mass index (BMI) and 25(OH)D in the diastolic dysfunction group decreased, and LDLC increased(P＜0.05). 25(OH)D level was a risk factor for both myocardial remodeling and diastolic dysfunction in patients(P＜0.05). 25(OH)D level has good diagnostic efficacy for myocardial remodeling and diastolic dysfunction. Conclusion25(OH)D level is an independent risk factor for cardiac remodeling and left ventricular diastolic function in patients with hypertension complicated with coronary heart disease, and early detection of 25(OH)D level is helpful for clinical diagnosis. |
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