| 李洪英,丁雪梅,高洁,余俊峰,符锦,马霞,沈亚娟.孕期血清维生素A、E和氧化应激损伤指标与子痫前期的相关性.[J].中南医学科学杂志.,2022,(4):517-520. |
| 孕期血清维生素A、E和氧化应激损伤指标与子痫前期的相关性 |
| Correlation between serum vitamins A, E and oxidative stress injury indexes with preeclampsia during pregnancy |
| 投稿时间：2021-03-04 修订日期：2021-11-23 |
| DOI：10.15972/j.cnki.43-1509/r.2022.04.012 |
| 中文关键词: 子痫前期 维生素A 维生素E 氧化应激损伤 |
| 英文关键词:preeclampsia vitamin A vitamin E oxidative stress injury |
| 基金项目:国家卫生计生委医药卫生科技发展研究中心资助项目(W2015CAE040) 作者简介:李洪英,主任医师,研究方向为子痫前期的诊疗,E-mail为1916038654@qq.com。通信作者丁雪梅,硕士,主治医师,研究方向为子痫前期的诊疗,E-mail为xiaoxuewell@163.com。 |
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| 中文摘要: |
| 目的探讨孕妇孕期血清维生素(Vit)A、E水平及氧化应激损伤指标与子痫前期(PE)发生及病情进展的相关性。方法选取PE孕妇704例为PE组,其中轻度PE组358例,重度PE组346例；非PE正常孕妇6 293例为对照组。比较各组孕妇血清VitA、VitE与氧化应激水平,分析各指标与PE的相关性。结果PE组VitA、E及总抗氧化能力(T-AOC)、基质金属蛋白酶-9(MMP-9)、超氧化物歧化酶(SOD)低于对照组,重度PE组低于轻度PE组;PE组VitA、E缺乏率及活性氧(ROS)高于对照组,重度PE组高于轻度PE组(P＜0.05)。血清VitA、E与T-AOC、MMP-9、SOD呈正相关,与ROS呈负相关(P＜0.05)。血清VitA、E、T-AOC、MMP-9、SOD与PE病情程度呈负相关(P＜0.05),ROS与PE病情程度呈正相关(P＜0.05)。VitA、E缺乏及ROS是PE发生的危险因素(P＜0.05),VitA、E缺乏及ROS、年龄≥35岁是重度PE的危险因素(P＜0.05),T-AOC、MMP-9、SOD是PE及重度PE的保护因素(P＜0.05)。结论PE孕妇血清VitA、E含量相对缺乏,且VitA、E水平及氧化应激指标与PE的发生及病情进展密切相关。 |
| 英文摘要: |
| To investigate the correlation between serum vitamin (Vit) A, E levels and oxidative stress injury indexes during pregnancy and the occurrence and progression of preeclampsia (PE). Methods704 pregnant women with PE were selected as PE group, of which 358 cases were mild PE group and 346 cases were severe PE group. 6 293 normal pregnant women without PE were selected as control group. The levels of serum VitA, VitE and oxidative stress injury indexes of pregnant women in each group were compared, the correlation between each index and PE were compared. ResultsThe levels of VitA, VitE, total antioxidant capacity (T-AOC), matrix metalloproteinase 9 (MMP-9), and superoxide dismutase (SOD) in the PE group were lower than those of the control group, and the severe PE group were lower than those of the mild PE group. The rates of VitA, VitE deficiency and reactive oxygen species (ROS) in the PE group were higher than those of the control group, and the severe PE group were higher than those of the mild PE group(P＜0.05). Serum VitA and VitE were positively correlated with T-AOC, MMP-9 and SOD, and negatively correlated with ROS(P＜0.05). Serum VitA, VitE, T-AOC, MMP-9, SOD were negatively correlated with the severity of PE(P＜0.05), and ROS was positively correlated with the severity of PE(P＜0.05). VitA, VitE deficiency and ROS were risk factors for the occurrence of PE(P＜0.05), VitA, VitE deficiency and ROS, age≥35 years were risk factors for severe PE(P＜0.05), T-AOC, MMP-9, SOD were protective factors for PE and severe PE(P＜0.05). ConclusionThe levels of serum VitA, VitE were relatively deficient in pregnant women of PE, and the levels of VitA, VitE and oxidative stress injury indexes were closely related to the occurrence and progression of PE. |
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