杨慧婷,叶旭,师颖瑞.醛酮还原酶1B10与肿瘤发展的研究进展.[J].中南医学科学杂志.,2022,(3):454-457.
醛酮还原酶1B10与肿瘤发展的研究进展
Advances in AKR1B10 with tumor progression
投稿时间:2021-09-12  修订日期:2022-02-26
DOI:10.15972/j.cnki.43-1509/r.2022.03.038
中文关键词:  醛酮还原酶1B10  基因调控  肿瘤标志物  AKR1B10抑制剂
英文关键词:AKR1B10  gene regulation  tumor markers  AKR1B10 inhibitor
基金项目:国家科技重大专项(民口)课题(2020ZX09201-019) 作者简介:杨慧婷,硕士研究生,住院医师,研究方向为肿瘤放射治疗学,E-mail为1163431427@qq.com。通信作者师颖瑞,博士,主任医师,硕士研究生导师,研究方向为肿瘤放射治疗学,E-mail为shiyingrui@hnszlyy.com。
作者单位E-mail
杨慧婷 南华大学衡阳医学院 湖南省肿瘤医院协助培养基地,湖南省衡阳市 421001 e-mail为1163431427@qq.com,e-mail为shiyingrui@hnszlyy.com 
叶旭 湖南省肿瘤医院,湖南省长沙市 410013  
师颖瑞 湖南省肿瘤医院,湖南省长沙市 410013 e-mail为1163431427@qq.com,e-mail为shiyingrui@hnszlyy.com 
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中文摘要:
      醛酮还原酶1B10(AKR1B10)是醛酮还原酶(AKR)超家族的成员之一,参与了多种肿瘤的发生及发展,是一种新型的肿瘤标志物。近年来,关于AKR1B10抑制剂的研究也越来越多,并有望成为新型的抗癌药物。本文主要就AKR1B10的结构及功能、促进不同肿瘤发生发展的机制、作为血清肿瘤标志物的应用、耐药性及其抑制剂的应用等方面进行综述。
英文摘要:
      Aldo-keto reductase 1B10(AKR1B10), a member of the superfamily of aldo-keto reductase (AKR), is involved in the occurrence and development of a variety of tumors and is a novel tumor marker. There are more and more studies on AKR1B10 inhibitors and they are expected to become new anticancer drugs. The structure and functions of AKR1B10, the mechanisms promoted in different tumor development, the application of AKR1B10 as a serum tumor marker, drug resistance and its inhibitors were reviewed.
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