| 李梅,郑绥丽,刘楚.超声造影TIC定量参数在乳腺癌分期早期诊断中的应用.[J].中南医学科学杂志.,2022,(3):388-390, 394. |
| 超声造影TIC定量参数在乳腺癌分期早期诊断中的应用 |
| Application value of TIC quantitative parameters of contrast-enhanced ultrasound in the early diagnosis of clinical staging of breast cancer |
| 投稿时间：2021-07-28 修订日期：2022-01-08 |
| DOI：10.15972/j.cnki.43-1509/r.2022.03.019 |
| 中文关键词: 乳腺癌 超声造影时间-强度曲线 TNM分期 分子生物学标志物 |
| 英文关键词:breast cancer time-intensity curve of contrast-enhanced ultrasound TNM staging molecular biomarkers |
| 基金项目:广西省医疗卫生适宜技术开发与推广应用项目(S2020030) 作者简介:李梅,硕士,副主任医师,研究方向为超声造影、介入,E-mail为bangf04912@163.com。 |
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| 中文摘要: |
| 目的探究乳腺癌患者超声造影时间-强度曲线(TIC)参数与其分子生物学标志物的相关性。方法回顾性分析109例乳腺癌患者临床资料,根据其TNM分期分为中早期组和晚期组。比较两组TIC相关参数和分子生物学标志物水平,采用ROC曲线分析TIC相关参数对乳腺癌分期的评估效能。结果晚期组TIC相对上升斜率、达峰强度、曲线下面积大于中早期组,TIC相对达峰时间短于中早期组(P＜0.05)。晚期组雌激素受体、孕激素受体、人表皮生长因子-2、增殖相关核抗原ki-67阳性表达等均高于中早期组(P＜0.05)。TIC相对上升斜率、达峰时间、达峰强度、曲线下面积评估乳腺癌TNM分期的AUC分别为0.878、0.755、0.843、0.796。结论乳腺癌患者TIC参数可有效反映乳腺癌进展情况,且其获取方式更具无创性,可为临床评估乳腺癌分期提供参考。 |
| 英文摘要: |
| To explore the correlation between time-intensity curve (TIC) parameters of contrast-enhanced ultrasound and molecular biomarkers in patients with breast cancer. MethodsThe clinical data of 109 patients with breast cancer were retrospectively analyzed. According to the TNM staging, the patients were divided into early-to-mid stage group and advanced stage group. The TIC related parameters and molecular biomarkers were compared between the two groups. Receiver operating characteristic curve was used to analyze the efficiency of TIC related parameters on breast cancer staging. ResultsThe relative rise slope of TIC, relative peak intensity of TIC and relative area under the curve of TIC in advanced stage group were greater than those in early-to-mid stage group, and the relative peak time of TIC was shorter than that in early-to-mid stage group (P＜0.05).The positive expressions of estrogen receptor, progesterone receptor, human epidermal growth factor-2 and ki-67 in advanced stage group were higher than those in early-to-mid stage group (P＜0.05). The AUC values of TIC relative rise slope, TIC relative peak time, TIC relative peak intensity, TIC relative area under the curve in assessing TNM staging of breast cancer were 0.878,0.755,0.843 and 0.796 respectively. ConclusionTIC parameters can effectively reflect the tumor progression of patients with breast cancer, and the parameter acquisition method is more noninvasive and can provide reference for clinical assessment of breast cancer staging. |
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