| 秦瑜玲,隋娟,侯梓桐,孟云霄,周天一,陈瑞雪.基于生物信息学探讨复发性流产与系统性红斑狼疮的关系.[J].中南医学科学杂志.,2022,(3):354-357. |
| 基于生物信息学探讨复发性流产与系统性红斑狼疮的关系 |
| Relationship between recurrent spontaneous abortion and systemic lupus erythematosus based on bioinformatics |
| 投稿时间：2021-06-17 修订日期：2021-12-20 |
| DOI：10.15972/j.cnki.43-1509/r.2022.03.010 |
| 中文关键词: 复发性流产 系统性红斑狼疮 生物信息学 相互关系 |
| 英文关键词:recurrent spontaneous abortion systemiclupus erythematosus bioinformatics relationship |
| 基金项目:国家自然科学基金项目(82074484)；中央本级重大增减支项目(2060302)；中国中医科学院基本科研业务费自主选题项目(ZZ070843) 作者简介:秦瑜玲,硕士研究生,研究方向为中医药治疗不孕不育、月经失调、盆腔炎、妇科肿瘤等疾病,E-mail为xiaohan199777@126.com。通信作者陈瑞雪,博士,主任医师,教授,博士研究生导师,研究方向为中医药治疗不孕不育、月经失调、盆腔炎、妇科肿瘤等疾病,E-mail为chenruixue@gamyy.cn。 |
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| 中文摘要: |
| 目的基于生物信息学方法探讨复发性流产与系统性红斑狼疮之间的相互关系。方法在相关人类疾病数据库(GeneCards、OMIM、Durgbank)中分别以复发性流产及系统性红斑狼疮筛选靶基因,整合后映射两组疾病靶点得到交集靶点,利用Cytoscape软件按照Degree值大小筛选出核心交集靶点,并利用DAVID数据库进行KEGG通路及GO分析。结果复发性流产与系统性红斑狼疮的核心交集靶点为信号传导与转录激活因子3(STAT3)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、血管内皮生长因子A(VEGFA)、Janus激酶2(JAK2)等,相关通路集中在PI3K-Akt信号通路、JAK/STAT信号通路、HIF-1信号通路。结论复发性流产与系统性红斑狼疮在基因靶点与信号通路方面存在大量重合,提示两种疾病的分子机制存在密切联系,同时也给临床发掘诊断标志物以及药物治疗提供新思路。 |
| 英文摘要: |
| To investigate the relationship between recurrent spontaneous abortion and systemic lupus erythematosus based on bioinformatics method. MethodsThe target genes were screened for recurrent spontaneous abortion and systemic lupus erythematosus in the relevant human disease databases (GeneCards, OMIM, Durgbank), respectively. After integration, the two groups of disease targets were mapped to obtain the intersection targets. Cytoscape software was used to screen out according to the degree value. Core intersection targets, and KEGG pathway and GO analysis were performed using the DAVID database. ResultsThe core intersection targets of recurrent spontaneous abortion and systemic lupus erythematosus were:signal transduction and activator of transcription 3 (STAT3), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNF), vascular endothelial growth factor A (VEGFA), Janus kinase 2 (JAK2), etc. The related pathways are concentrated in the PI3K-Akt signaling pathway, the JAK/STAT signaling pathway, and the HIF-1 signaling pathway. ConclusionsRecurrent abortion and systemic lupus erythematosus have a lot of overlap in gene targets and signal pathways, suggesting that there is a close relationship between the molecular mechanisms of the two diseases. At the same time, it also provides new ideas for clinical exploration of diagnostic markers and drug treatment. |
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