| 程爱兰,郑露露.硫化氢在呼吸系统疾病中的作用研究进展.[J].中南医学科学杂志.,2022,(3):313-318. |
| 硫化氢在呼吸系统疾病中的作用研究进展 |
| Advanced research progress on the role of hydrogen sulfide in respiratory diseases |
| 投稿时间：2021-11-08 修订日期：2022-01-20 |
| DOI：10.15972/j.cnki.43-1509/r.2022.03.001 |
| 中文关键词: 硫化氢 呼吸系统疾病 肺炎 急性肺损伤 哮喘 慢性阻塞性肺疾病 肺癌 |
| 英文关键词:H2S respiratory diseases pneumonia acute lung injury asthma chronic obstructive pulmonary disease lung cancer |
| 基金项目:国家自然科学基金项目(81072198,81372894)；湖南省自然科学基金项目(2021JJ30589) 作者简介:通信作者程爱兰,博士,教授,硕士研究生导师,研究方向为恶性肿瘤蛋白质组学,E-mail为375355191@qq.com。郑露露,硕士研究生,研究方向为基础病理学,E-mail为1987162186@qq.com。 |
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| 中文摘要: |
| 呼吸系统疾病的发生率位于各系统疾病之首,随着其发病率的逐年攀升,呼吸系统疾病的预防、诊断和治疗也日益被重视。除一氧化氮和一氧化碳之外,硫化氢(H2S)是第3种重要的气体信号分子,具有典型的恶臭气味。越来越多的研究发现其与肺部炎症、慢性阻塞性肺疾病、肺癌等多种呼吸系统疾病的发生发展有着密切联系,在呼吸系统中兼具保护与损伤两种相互矛盾的作用,研究H2S在呼吸系统疾病中的作用及其相应的病理生理学机制对呼吸系统疾病的诊治具有重要意义。因此,本文对H2S的产生过程、H2S在呼吸系统中的双向作用以及在常见呼吸系统疾病中的具体作用进行了简要概述,为其临床应用提供理论依据。 |
| 英文摘要: |
| The incidence rate of respiratory diseases is the highest among diseases of various systems throughout the body. As its incidence is increasing gradually, considerable attention is being paid to its prevention, diagnosis and treatment. The hydrogen sulfide (H2S), with a typical malodorous odor, has recently been recognized as the third important gas-signaling molecule, besides nitric oxide and carbonmonoxide. There is increasing evidence indicating an association between H2S and the occurrence and development of various respiratory diseases, such as pulmonary inflammation, chronic obstructive pulmonary disease, lung cancer, etc. However, it has two contradictory effects on the respiratory system, both protection and injury. Studying the role of H2S in respiratory diseases and its corresponding pathophysiological mechanism is greatly significant for the diagnosis and treatment of respiratory diseases. Therefore, this review provides a brief overview of the production process of H2S, the double-sided effects of H2S in the respiratory system, and the specific role in common respiratory diseases are reviewed in this article, hoping to provide a theoretical basis for its clinical application. |
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