| 殷芳,何雪.云芝胞内糖肽联合左氧氟沙星治疗肺结核的疗效及对免疫功能的影响.[J].中南医学科学杂志.,2022,(2):223-226. |
| 云芝胞内糖肽联合左氧氟沙星治疗肺结核的疗效及对免疫功能的影响 |
| Effect of intracellular glycopeptide combined with levofloxacin in the treatment of pulmonary tuberculosis and its effect on immune function |
| 投稿时间：2021-08-24 修订日期：2021-10-20 |
| DOI：10.15972/j.cnki.43-1509/r.2022.02.016 |
| 中文关键词: 云芝胞内糖肽 左氧氟沙星 肺结核 痰菌阴转率 免疫功能 |
| 英文关键词:intracellular glycoseptide of Glucoderma spp levofloxacin tuberculosis sputum negative conversion rate immune function |
| 基金项目:重庆市技术创新与应用发展专项重点项目(cstc2019jscx-gksb X0064) 作者简介:殷芳,硕士,住院医师,研究方向为感染病学及炎症因子研究,E-mail为Ahappy2021@126.com。通信作者何雪,硕士,住院医师,研究方向为慢性肾脏病、血液透析、腹膜透析,E-mail为hxsunshine90@163.com。 |
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| 中文摘要: |
| 目的观察云芝胞内糖肽联合左氧氟沙星治疗肺结核的疗效及对免疫功能的影响。方法将本院192例肺结核患者随机均分为常规治疗组和联合治疗组,常规治疗组予以常规抗结核方案治疗,联合治疗组在常规治疗组基础上,予以云芝胞内糖肽联合左氧氟沙星治疗。检测两组Th1、Th2细胞水平及血清白细胞介素-6(IL-6)、C反应蛋白(CRP)的水平。观察两组痰菌阴转率、病灶吸收率、空洞闭合率及疗效和不良反应。结果治疗后,两组Th1细胞水平较治疗前升高,Th2细胞、IL-6、CRP水平较治疗前降低(P＜0.05),且联合治疗组Th1细胞水平高于常规治疗组,Th2细胞、IL-6、CRP水平低于常规治疗组(P＜0.05)。联合治疗组痰菌阴转率、病灶吸收率、空洞闭合率均高于常规治疗组(P＜0.05)。治疗后,联合治疗组总有效率高于常规治疗组(P＜0.05)。联合治疗组不良反应发生率低于常规治疗组(P＜0.05)。结论云芝胞内糖肽联合左氧氟沙星可改善肺结核患者的临床症状,提高其疗效,降低不良反应且具有增强免疫及抗感染的优势。 |
| 英文摘要: |
| To observe the effect of intracellular glycopeptide combined with levofloxacin in the treatment of pulmonary tuberculosis and its effect on immune function. Methods192 patients with tuberculosis in our hospital were randomly divided into conventional treatment group and combined treatment group. The conventional treatment group was treated with conventional anti-tuberculosis regimen, while the combined treatment group was treated with intracellular glycopeptide combined with levofloxacin on the basis of conventional treatment group. Th1 and Th2 cell levels and serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels were detected. The sputum negative conversion rate, focus absorption rate, cavity closure rate, curative effect and adverse reactions were observed. ResultsAfter treatment, the levels of Th1 cells in both groups were increased compared with before treatment, and the levels of Th2 cells, IL-6 and CRP were decreased compared with before treatment (P＜0.05), and the levels of Th1 cells in the combined treatment group were higher than those in the conventional treatment group, while the levels of Th2 cells, IL-6 and CRP were lower than those in the conventional treatment group (P＜0.05). The negative transformation rate of sputum, absorption rate of lesion and cavity closure rate of combined treatment group were higher than those of conventional treatment group (P＜0.05). After treatment, the total effective rate of combined treatment group was higher than that of conventional treatment group (P＜0.05). The incidence of adverse reactions in combined treatment group was lower than that in conventional treatment group (P＜0.05). ConclusionCoriolus versicolor intracellular glycopeptide combined with levofloxacin can improve the clinical symptoms and curative effect of patients with pulmonary tuberculosis, reduce adverse reactions and has the advantages of immune enhancement and antiinfection. |
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