| 吴移谋,黄燕茹,卢思敏,王建业.胞内菌与宿主自噬的相互作用.[J].中南医学科学杂志.,2022,(2):157-161. |
| 胞内菌与宿主自噬的相互作用 |
| Intracellular bacterial interaction with host autophagy |
| 投稿时间：2021-09-08 修订日期：2021-10-12 |
| DOI：10.15972/j.cnki.43-1509/r.2022.02.001 |
| 中文关键词: 细胞自噬 胞内菌 自噬逃逸 |
| 英文关键词:autophagy intracellular bacterial autophagy escape |
| 基金项目:国家自然科学基金(31872643) 作者简介:吴移谋,教授,博士研究生导师,研究方向为衣原体、梅毒螺旋体、支原体等特殊病原体的致病机制,快速诊断与防治,E-mail为yimouwu@sina.com。黄燕茹,硕士研究生,研究方向为衣原体预防与治疗,E-mail为2392367356@qq.com。 |
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| 中文摘要: |
| ]自噬是一种进化保守的分解代谢过程,通过清除受损的细胞器和错误折叠的蛋白质,以维持细胞稳态。病原体感染触发的自噬可特异性地抑制机体内细菌的复制,从而保护细胞免受伤害。然而,许多病原微生物已进化出一系列对抗自噬的机制。本文综述聚焦胞内菌和宿主细胞之间的相互作用,简要概述胞内菌如何被自噬靶向清除,以及胞内菌如何调控自噬以促进其在细胞内的生存与繁殖。 |
| 英文摘要: |
| Autophagy is an evolutionarily conserved self-balancing process that plays an important role in maintaining cell homeostasis by targeting damaged organelles and misfolded proteins to lysosomes for degradation. Autophagy triggered by pathogen infection can specifically inhibit the replication of bacteria in the host cell, thereby protecting cells from harm. In turn, many pathogenic microorganisms developed diverse strategies to avoid autophagy. In this review, we focus on the interaction between intracellular bacteria and host autophagy. We then dicusses how intracellular bacteria are targeted and eliminated by autophagy, and how intracellular bacteria manipulate autophagy to promote their intracellular colonization and growth. |
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