| 刘慧磷,谭洁琼,王芳.脂质代谢紊乱与神经退行性疾病关系的研究进展.[J].中南医学科学杂志.,2022,(1):149-152. |
| 脂质代谢紊乱与神经退行性疾病关系的研究进展 |
| Research progress on the relationship between lipid metabolism and neurodegenerative diseases |
| 投稿时间：2021-05-17 修订日期：2021-08-23 |
| DOI：10.15972/j.cnki.43-1509/r.2022.01.036 |
| 中文关键词: 脂质代谢 神经退行性疾病 中枢神经系统 阿兹海默病 帕金森病 |
| 英文关键词:lipid metabolism neurodegenerative diseases central nervous system Alzheimer's disease Parkinson's disease |
| 基金项目:湖南省教育厅基金项目(17C1396)；国家级大学生创新创业训练计划项目(201710555009) 作者简介:刘慧磷,硕士研究生,研究方向为神经退行性疾病的发病机制,E-mail为1301501609@qq.com。通信作者王芳,博士研究生,讲师,研究方向为干细胞移植与脑血管疾病,E-mail为514894146@qq.com。 |
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| 中文摘要: |
| 脑内脂质是神经细胞中发挥结构功能和生理作用的主要成分,大脑包含成千上万种脂类,但复杂的脂类成分多样性和每种脂类的功能目前研究尚不是很清楚。越来越多研究表明脂质代谢参与了多种神经退行性疾病的病理进展,尤其是对于阿兹海默病(AD)和帕金森病(PD)的发病起着重要的作用。本综述主要总结了胆固醇、脂肪酸、甘油磷脂和鞘脂等几类主要脂质在AD和PD及其他常见神经退行性疾病中的作用。 |
| 英文摘要: |
| Brain lipids are the main components that play structural and physiological roles in nerve cells. The brain contains thousands of lipids, but the complex diversity of lipids and the functions of each lipid are not well understood. More and more studies have shown that lipid metabolism plays an important role in the pathogenesis of many neurodegenerative diseases, especially Alzheimer's disease(AD) and Parkinson's disease(PD). This review mainly summarizes the role of several major lipids such as cholesterol, fatty acids, glycerophospholipids and sphingolipids in AD, PD and other common neurodegenerative diseases. |
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