| 曹长杰,刘学勤,张广亚,王佳慧,刘楠楠,刘云.丙戊酸钠结合富马酸喹硫平对双相障碍躁狂患者临床疗效及BRMS、SDSS评分的影响.[J].中南医学科学杂志.,2022,(1):125-127. |
| 丙戊酸钠结合富马酸喹硫平对双相障碍躁狂患者临床疗效及BRMS、SDSS评分的影响 |
| Effect of sodium valproate combined with quetiapine fumarate on BRMS and SDSS scores of manic patients with bipolar disorder |
| 投稿时间：2021-03-18 修订日期：2021-05-08 |
| DOI：10.15972/j.cnki.43-1509/r.2022.01.030 |
| 中文关键词: 丙戊酸钠 富马酸喹硫平 双相障碍躁狂 Bech-Rafaelsen狂躁量表 社会功能缺陷量表 |
| 英文关键词:sodium valproate quetiapine fumarate bipolar disorder mania Bech-Rafaelsen mania scale social function deficiency scale |
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| 中文摘要: |
| 目的探讨丙戊酸钠结合富马酸喹硫平对双相障碍躁狂患者临床疗效及Bech-Rafaelsen狂躁量表(BRMS)、社会功能缺陷量表(SDSS)评分的影响。 方法随机将88例双相障碍躁狂患者分为两组,对照组44例用富马酸喹硫平治疗,观察组44例采用丙戊酸钠结合富马酸喹硫平治疗。比较两组临床疗效、BRMS评分、SDSS评分、神经肽Y(NPY)、P物质(SP)水平及不良反应发生率。 结果观察组临床疗效总有效率高于对照组；治疗后两组BRMS、SDSS评分均较治疗前降低,且观察组降低更为显著(P＜0.05)。治疗后观察组血浆NPY高于对照组, SP低于对照组(P＜0.05)。治疗期间两组不良反应发生率差异无显著性(P＞0.05)。 结论丙戊酸钠结合富马酸喹硫平可有效抑制双相障碍躁狂发作,改善患者社会功能,用药安全,值得临床推广。 |
| 英文摘要: |
| To explore the effects of sodium valproate combined with quetiapine fumarate on the clinical efficacy and the scores of Bech-Rafaelsen mania scale (BRMS) and social dysfunction scale (SDSS). Methods88 patients with bipolar disorder mania were randomly divided into two groups. 44 patients in the control group were treated with quetiapine fumarate and 44 patients in the observation group were treated with sodium valproate combined with quetiapine fumarate. The clinical efficacy, BRMS score, SDSS score, neuropeptide Y (NPY), substance P (SP) level and the incidence of adverse reactions were compared between the two groups. ResultsThe total effective rate of the observation group was higher than that of the control group; After treatment, the scores of BRMS and SDSS in the two groups were lower than those before treatment, and the decrease was more significant in the observation group (P＜0.05). After treatment, plasma NPY in the observation group was higher than that in the control group, and SP was lower than that in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P＞0.05). ConclusionSodium valproate combined with quetiapine fumarate can effectively inhibit the manic attack of bipolar disorder, improve the social function of patients, and the medication is safe, which is worthy of clinical promotion. |
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