| 时彬,卢运,魏晶晶.酒石酸美托洛尔联合贝那普利对高血压合并心力衰竭患者心功能指标、血压昼夜节律变化及心率变异性的影响.[J].中南医学科学杂志.,2022,(1):93-97. |
| 酒石酸美托洛尔联合贝那普利对高血压合并心力衰竭患者心功能指标、血压昼夜节律变化及心率变异性的影响 |
| Effects of metoprolol tartrate sustained-release tablets combined with benazepril on circadian rhythm changes of cardiac function indexes and heart rate variability in patients with hypertension complicated with heart failure |
| 投稿时间：2021-04-13 修订日期：2021-08-25 |
| DOI：10.15972/j.cnki.43-1509/r.2022.01.022 |
| 中文关键词: 酒石酸美托洛尔 高血压合并心力衰竭 心功能 血压昼夜节律变化 心率变异性 |
| 英文关键词:metoprolol tartrate hypertension complicated with heart failure cardiac function circadian rhythm change heart rate variability |
| 基金项目: |
|
| 摘要点击次数: 404 |
| 全文下载次数: 486 |
| 中文摘要: |
| 目的研究酒石酸美托洛尔联合贝那普利对高血压(EH)合并心力衰竭(FH)患者心功能指标、血压昼夜节律变化及心率变异性的影响。 方法将高血压合并心力衰竭患者144例随机均分为贝那普利组(贝那普利治疗)和联合组(酒石酸美托洛尔联合贝那普利治疗)。比较两组治疗前后心功能指标、血压昼夜节律变化、心率变异性,并用Logistic回归分析其影响因素。 结果治疗后两组心功能指标、血压昼夜节律变化和心率变异性指标较治疗前均明显改善,且联合组较贝那普利组改善更为显著(P＜0.05)。影响两药联合治疗效果的因素有年龄、NYHA分级、冠心病、瓣膜病、左心室射血分数、肺部啰音、心律失常、脑钠肽治疗、肺动脉高压。 结论酒石酸美托洛尔联合贝那普利治疗高血压合并心力衰竭疗效显著,有助于提高患者心功能,改善血压昼夜节律变化和心率变异性,预后安全,具有临床推广应用价值。 |
| 英文摘要: |
| To study the effects of metoprolol tartrate combined with benazepril on cardiac function, circadian rhythm and heart rate variability in patients with essential hypertension (EH) and heart failure (FH). MethodsOne hundred and forty-four patients with hypertension complicated with heart failure were randomly divided into benazepril group (treated with benazepril) and combined group (treated with metoprolol tartrate combined with benazepril). Cardiac function, circadian rhythm, and heart rate variability were compared between the two groups before and after treatment, and the influencing factors were analyzed by Logistic regression. ResultsAfter treatment, the indexes of cardiac function, blood pressure circadian rhythm and heart rate variability were significantly improved in both groups, and the improvement in the combined group was more significant than that in the benazepril group (P＜0.05). The factors influencing the efficacy of the combination therapy were age, NYHA grade, coronary heart disease, valvular disease, left ventricular ejection fraction, pulmonary rales, arrhythmia, brain natriuretic peptide therapy and pulmonary hypertension. ConclusionMetoprolol tartrate combined with benazepril in the treatment of hypertension complicated with heart failure has a significant effect, which is helpful to improve the heart function of patients, improve the circadian rhythm and heart rate variability, and has a safe prognosis and clinical application value. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|