| 周飞,富晓旭,高鸿.老年骨质疏松症合并肌少症患者营养状态及血清生物化学指标的变化.[J].中南医学科学杂志.,2021,(6):683-686. |
| 老年骨质疏松症合并肌少症患者营养状态及血清生物化学指标的变化 |
| Changes of nutritional status and serum biochemical indicators in elderly patients with osteoporosis complicated with sarcopenia |
| 投稿时间：2021-02-18 修订日期：2021-06-07 |
| DOI：10.15972/j.cnki.43-1509/r.2021.06.016 |
| 中文关键词: 老年人群 骨质疏松症 肌少症 营养状态 生物化学指标 |
| 英文关键词:elderly population osteoporosis sarcopenia nutritional status biochemical indicators |
| 基金项目:2019年四川省干部保健科研课题(川干研2019-606) 作者简介:周飞,硕士,研究方向为内分泌、老年疾病的诊治,E-mail为bettyi2233@163.com。 |
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| 中文摘要: |
| 目的研究老年骨质疏松症(OP)合并肌少症患者营养状态和血清生物化学指标的变化及两者之间的关系。 方法选取老年OP合并肌少症患者102例为观察组,同期健康体检者100例为对照组。根据微型营养评价(MNA)量表评估营养状态,按营养状态结果将其分亚组。检测并比较各组血清生物化学指标。另采用Pearson积差系数分析MNA评分和生物化学指标的相关性。 结果观察组体质指数、基础代谢率、腰椎L2~4骨密度、上臂肌围、MNA评分、血红蛋白、白蛋白、前白蛋白、甘油三酯和总胆固醇水平均低于对照组(P＜0.05)。观察组血清磷高于对照组(P＜0.05)。观察组血清钙、维生素D3、骨碱性磷酸酶(BALP)及Ⅰ型胶原交联C末端肽(ICTP)水平均低于对照组,且随营养状态改善呈明显上升趋势(P＜0.05)。MNA评分与血清钙、维生素D3、BALP和ICTP呈明显正相关(P＜0.05)。 结论老年OP合并肌少症患者营养状态与血清生物化学指标存在明显相关性,提升患者营养状态可能对控制病情进展和改善预后具有积极作用。 |
| 英文摘要: |
| To study the changes of nutritional status and serum biochemical indicators in elderly patients with osteoporosis (OP) complicated with sarcopenia and the relationship between them. Methods102 elderly patients with OP and sarcopenia were enrolled as observation group, and 100 healthy people with physical examination during the same period were selected as control group. The nutritional status was evaluated by mini nutritional assessment (MNA) scale, and the patients were divided into subgroups according to nutritional status results. Serum biochemical indicators of each group were detected and compared, and Pearson product-moment coefficient was used to analyze the correlation between MNA score and biochemical indicators. ResultsThe body mass index (BMI), basal metabolic rate (BMR), lumbar L2~4 bone mineral density (BMD), mid arm muscle circumference (MAMC), MNA score and levels of hemoglobin, albumin, prealbumin, triglyceride and total cholesterol in observation group were lower than those in control group (P＜0.05). Serum phosphorus in observation group was higher than that in control group (P＜0.05). The levels of serum calcium, 25-hydroxyvitamin D3, bone alkaline phosphatase (BALP) and carboxytenninal telopeptide of type I collagen (ICTP) were lower in observation group than those in control group, and the levels were significantly increased with the improvement of nutritional status (P＜0.05). MNA score was significantly positively correlated with serum calcium, 25(OH)D3, BALP and ICTP (P＜0.05). ConclusionsThe nutritional status of elderly patients with OP and sarcopenia has a significant correlation with serum biochemical indicators. Improving the nutritional status of patients may have a positive effect on controlling disease progression and improving prognosis. |
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