| 刘受祥,叶晓敏,张敏艳,杨德云,彭慧,颜丽娟.呼吸道病毒和炎症因子与热性惊厥发病的相关性.[J].中南医学科学杂志.,2021,(6):640-643. |
| 呼吸道病毒和炎症因子与热性惊厥发病的相关性 |
| Correlation between respiratory viruses and inflammatory factors in the pathogenesis of febrile seizures |
| 投稿时间：2020-12-03 修订日期：2021-09-03 |
| DOI：10.15972/j.cnki.43-1509/r.2021.06.005 |
| 中文关键词: 热性惊厥 白细胞介素-6 白细胞介素-10 肿瘤坏死因子-α 呼吸道病毒 |
| 英文关键词:febrile seizures interleukin-6 interleukin-10 tumor necrosis factor-α respiratory viruses |
| 基金项目:湖南省自然科学基金项目(2019JJ60090) 作者简介:刘受祥,主任医师,研究方向为儿童急救,E-mail为1137585277@qq.com。 |
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| 中文摘要: |
| 目的分析呼吸道病毒与炎症因子在热性惊厥(FS)发病中的相关性。方法选取130例热性惊厥患儿为FS组,同期51例有发热无惊厥的呼吸道感染患儿作为对照组。用免疫荧光法检测两组患儿鼻咽部脱落细胞病毒抗原。用流式细胞仪检测两组血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)及肿瘤坏死因子-α(TNF-α)表达水平。结果FS组患儿中流感病毒A感染率明显高于对照组(P＜0.05),IL-6、IL-10及TNF-α表达水平显著高于对照组(P＜0.05)。FS组中复杂性热性惊厥患儿血清IL-6表达水平明显高于单纯性热性惊厥患儿(P＜0.05)。流感病毒A感染患儿IL-6、IL-10表达水平明显高于其他病毒感染患儿。结论在呼吸道病毒介导的FS患儿中,血清炎症因子的升高是病毒感染诱发FS发作的因素之一。IL-6升高可能促FS发作,IL-10升高与机体的保护性免疫有关。 |
| 英文摘要: |
| To analyze the relationship between respiratory viruses and inflammatory factors in the pathogenesis of febrile seizures (FS). Methods130 children with febrile seizures were selected as the subjects, at the same time, 51 children with respiratory tract infections with fever but no convulsions were selected as the control group. Immunofluorescence method was used to detect the virus antigen in the nasopharyngeal exfoliated cells of the subjects. Flow cytometry was used to detect the serum levels of interleukin-6(IL-6), interleukin-10(IL-10 )and tumor necrosis factor-α(TNF-α). ResultsThe infection rate of influenza A virus in FS group was significantly higher than that in control group, the levels of serum IL-6, IL-10 and TNF-α were significantly higher in the FS group than those in the control group (P＜0.05). The levels of serum IL-6 in complex febrile seizures group was significantly higher than that in simple febrile seizures group (P＜0.05). The expression levels of IL-6 and IL-10 in children infected with influenza A virus were significantly higher than those in children infected with other viruses. ConclusionsIn children with respiratory virus-mediated FS, the increase of serum inflammatory factors is one of the factors that cause the onset of FS. The increase of IL-6 may promote the onset of FS, and the increase of IL-10 is related to the body's protective immunity. |
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