| 赵怡,许翠萍.肠道微生物临床精准干预的研究进展.[J].中南医学科学杂志.,2021,(5):618-620. |
| 肠道微生物临床精准干预的研究进展 |
| Research progress on clinical precise intervention of intestinal microorganism |
| 投稿时间：2020-11-29 修订日期：2021-06-05 |
| DOI：10.15972/j.cnki.43-1509/r.2021.05.030 |
| 中文关键词: 肠道微生物 精准干预 新靶点 |
| 英文关键词:intestinal microorganisms accurate intervention new target |
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| 中文摘要: |
| 肠道微生物的组成和功能与宿主遗传和环境因素相关。肠道微生物失调常导致营养不良、肥胖症、糖尿病等疾病的发生。高通量测序和宏基因组学等新技术的不断开发和应用使肠道微生物成为临床精准干预的新靶点,然而在干预过程中常会发生明显的肠道微生物失衡,提示在临床实践中必须考虑到目标人群的适应证,慎重选择肠道微生物的干预策略。本文就肠道微生物组成与功能、临床精准干预新靶点、措施及前景进行综述。 |
| 英文摘要: |
| The composition and function of intestinal microorganisms are related to host genetic and environmental factors. Intestinal microbiota often causes malnutrition, obesity and diabetes. With the continuous development and application of new technologies such as high-throughput sequencing and metagenomics, intestinal microbiota has become a new target for clinical precise intervention. However, obvious imbalance of intestinal microbiota often occurs in the process of intervention, which indicates that the indications of target population must be considered in clinical practice, and the intervention strategy of intestinal microbiota must be carefully selected. This article reviews the composition and function of intestinal microorganisms, new targets, measures and prospects of clinical precise intervention. |
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