| 符兰芳,蒙绪标,张菊云,林珠,黄辛欣.维生素D水平对初诊2型糖尿病患者肠道菌群的影响.[J].中南医学科学杂志.,2021,(5):547-550. |
| 维生素D水平对初诊2型糖尿病患者肠道菌群的影响 |
| To study the effect of vitamin D level on the intestinal flora of newly diagnosed type 2 diabetes patients |
| 投稿时间：2021-03-07 修订日期：2021-03-30 |
| DOI：10.15972/j.cnki.43-1509/r.2021.05.012 |
| 中文关键词: 维生素D 2型糖尿病 肠道菌群 |
| 英文关键词:vitamin D type 2 diabetes intestinal flora |
| 基金项目:海南卫生健康委员会项目(15A200020) 作者简介:符兰芳,硕士,副主任医师,主要从事内分泌常见疾病的诊断和治疗,E-mail为fulanf@126.com。 |
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| 中文摘要: |
| 目的探讨维生素D(VitD)水平影响初诊2型糖尿病(T2DM)患者肠道菌群的状况。方法研究对象为165名未行降糖干预的初诊T2DM病人,按VitD水平分为VitD充足组80例和VitD缺乏或不足组85例,并将110位健康者归入对照组。比较3组间总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(IR)及肠道菌群分布情况。结果TC和TG各组间比较差异无显著性(P＞0.05)。VitD缺乏或不足组HOMA-IR、FPG、FINS较VitD充足组显著增高(P＜0.05)；VitD缺乏或不足组肠道菌群的物种丰度与多样性较VitD充足组明显降低(P＜0.05)。结论VitD不足或缺乏可使患者IR加剧,破坏了肠道菌群平衡,降低了肠道物种的丰富度和多样性。 |
| 英文摘要: |
| To investigate the effect of vitamin D (VitD) level on intestinal flora in newly diagnosed type 2 diabetes mellitus (T2DM) patients. Methods165 newly diagnosed T2DM patients without hypoglycemic intervention were divided into two groups according to VitD:VitD sufficient group (n＝80), VitD deficient or insufficient group (n＝85), and 110 healthy people were included in the control group. Total cholesterol (TC), triglyceride (TG), fasting plasma glucose(FPG), fasting insulin(FINS), insulin resistance index (IR) and intestinal flora were compared among the three groups. ResultsThere was no significant difference in TC and TG among groups (P＞0.05). HOMA-IR, FPG and FINS were significantly higher in VitD deficient group than in VitD sufficient group; The species richness and diversity of intestinal microflora in VitD deficient or insufficient groups were significantly lower than those in VitD sufficient group (P＜0.05). ConclusionThe deficiency of VitD can aggravate insulin resistance (IR), destroy the balance of intestinal flora, and reduce the richness and diversity of intestinal species. |
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