| 谭之能,吴国欢,冯元良,王金忠.NLRP3、HMGB1及TBIL在慢性阻塞性肺病患者外周血的表达意义及诊断价值.[J].中南医学科学杂志.,2021,(5):540-542, 563. |
| NLRP3、HMGB1及TBIL在慢性阻塞性肺病患者外周血的表达意义及诊断价值 |
| Expression and diagnostic value of NLRP3, HMGB1 and TBIL in peripheral blood of patients with chronic obstructive pulmonary disease |
| 投稿时间：2021-04-15 修订日期：2021-06-23 |
| DOI：10.15972/j.cnki.43-1509/r.2021.05.010 |
| 中文关键词: 核苷酸结合寡聚化结构域样受体蛋白3 高迁移率族蛋白B1 总胆红素 慢性阻塞性肺病 |
| 英文关键词:nucleotides bind to oligomeric domain-like receptor proteins3 high mobility group protein B1 total bilirubin chronic obstructive pulmonary disease |
| 基金项目:海南省自然科学基金青年基金项目(820QN405) 作者简介:谭之能,主治医师,研究方向为慢性阻塞性肺病及咳嗽变异性哮喘,E-mail为tanzhineng4433@163.com。 |
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| 中文摘要: |
| 目的探究核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、高迁移率族蛋白B1(HMGB1)及总胆红素(TBIL)在慢性阻塞性肺病(COPD)患者外周血的表达意义及诊断价值。方法选择COPD急性发作期75例为急性期组(根据病情严重程度分轻度组、中度组及重度组),稳定期60例为稳定期组,另选同期体检健康者60例为健康组。观察各组NLRP3、HMGB1及TBIL水平；相关性分析各指标与患者肺功能分级(GOLD)间关系；通过受试者工作特征曲线分析NLRP3、HMGB1及TBIL对COPD的诊断效能。结果NLRP3、HMGB1水平变化在急性期组、稳定期组、健康组和重度组、中度组、轻度组均依次降低(P＜0.05),而TBIL水平变化趋势与之相反(P＜0.05)。COPD患者NLRP3、HMGB1与GOLD分级呈正相关,TBIL与GOLD分级呈负相关(P＜0.05)。血清NLRP3、HMGB1、TBIL三者联合诊断COPD急性发作期和稳定期患者的诊断价值最高。结论COPD急性发作期患者NLRP3、HMGB1、TBIL水平较稳定期患者更为异常,与病情严重程度密切相关,且三者联合检测有助于COPD急性发作期及稳定期的诊断研究。 |
| 英文摘要: |
| To explore the expression significance and diagnostic value of nucleotides bind to oligomeric domon-like receptor protein 3(NLRP3), high mobility group protein B1 (HMGB1) and total bilirubin (TBIL) in peripheral blood of patients with chronic obstructive pulmonary disease. MethodsSeventy-five patients with acute onset of chronic obstructive pulmonary disease (COPD) were selected as the acute stage group (divided into mild group, moderate group and severe group according to the severity of the disease), 60 patients with stable COPD were selected as the stable stage group, and 60 healthy subjects were selected as the healthy group. The levels of NLRP3, HMGB1 and TBIL in each group were observed. Correlation analysis was used to study the relationship between each index and patients with lung function grade (GOLD); Receiver operating characteristic curve was used to analyze the diagnostic efficacy of NLRP3, HMGB1 and TBIL for COPD. ResultsThe variation trend of NLRP3 and HMGB1 levels was as follows:the acute stage, stable stage, healthy group and the severe stage, moderate group, mild group decreased in turn (P＜0.05), while the variation trend of TBIL levels was opposite (P＜0.05). In COPD patients, NLRP3 and HMGB1 were positively correlated with the global initiative for chronic obstructive pulmonary disease (GOLD) grade, while TBIL was negatively correlated with GOLD grade (P＜0.05). The combined diagnosis of serum NLRP3, HMGB1 and TBIL is of the highest diagnostic value in patients with acute episode and stable COPD. ConclusionsThe levels of NLRP3, HMGB1 and TBIL in patients with acute episode of COPD were more abnormal than those in patients with stable episode, which were closely related to the severity of the disease. Moreover, the combined detection of the three levels was helpful for the diagnosis of COPD in patients with acute episode and stable episode. |
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