| 刘建,崔翰文,张雪梅,刘琳琳.miR-17-5p在非小细胞肺癌患者中的表达及其与临床病理特征的相关性.[J].中南医学科学杂志.,2021,(5):528-531, 539. |
| miR-17-5p在非小细胞肺癌患者中的表达及其与临床病理特征的相关性 |
| Expression of miR-17-5p in patients with non-small cell lung cancer and its correlation with clinicopathological characteristics |
| 投稿时间：2020-12-31 修订日期：2021-03-20 |
| DOI：10.15972/j.cnki.43-1509/r.2021.05.007 |
| 中文关键词: 非小细胞肺癌 miR-17-5p 预后 |
| 英文关键词:non-small cell lung cancer miR-17-5p prognosis |
| 基金项目:黑龙江省卫生计生委科研项目(2017-473) 作者简介:刘建,硕士,主治医师,研究方向为肺间质纤维化、肺栓塞、慢性阻塞性肺疾病、肺癌等疾病的诊治,E-mail为fengxia19656@163.com。 |
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| 中文摘要: |
| 目的探讨miR-17-5p在非小细胞肺癌(NSCLC)患者中的表达差异及其与临床病理特征的相关性。 方法利用数据库分析miR-17-5p在NSCLC肿瘤组织与正常组织中的表达差异。分析60例NSCLC患者和60例健康受试者血清miR-17-5p表达,并结合临床资料分析其表达差异的临床意义；分析miR-17-5p、CEA、CYFRA21-1和CA125与临床病理特征的相关性。 结果数据库和临床分析发现,miR-17-5p在NSCLC组织和血清中的表达均显著高于健康对照组(P＜0.05),并且高表达患者的预后要比低表达患者差。通过AUC曲线测量的miR-17-5p诊断准确性为0.746,大于CEA、CYFRA21-1和CA125。临床分析发现,血清miR-17-5p高表达与患者的淋巴结转移相关。 结论血清miR-17-5p可作为潜在的NSCLC诊断和预后评价的分子标志物。NSCLC患者血清miR-17-5p表达升高,且与患者的预后关系密切。 |
| 英文摘要: |
| To evaluate microRNA-17-5p (miR-17-5p) expression in non-small cell lung cancer (NSCLC), and investigate its association with clinicopathological characteristics. MethodsThe expression differences of miR-17-5p between tumor tissues and normal tissues were analyzed by using the database. The expression of miR-17-5p of 60 NSCLC patients and 60 healthy subjects in serum was analyzed, and the clinical significance of the difference was analyzed combined with clinical data. The correlation of miR-17-5p, CEA, CYFRA21-1 and CA125 with clinicopathological characteristics was analyzed. ResultsAccording to database and clinical analysis, the expression of miR-17-5p in NSCLC tissue and serum was significantly higher than that of healthy control group (P＜0.05), and the prognosis of patients with high expression was worse than that of patients with low expression. The diagnostic accuracy of miR-17-5p measured by the AUC curve was 0.746, higher than that of CEA, CYFRA21-1 and CA125AUC. Clinical analysis found that the high expression of serum miR-17-5p was associated with lymph node metastasis in patient. ConclusionsSerum miR-17-5p can be used as a potential molecular marker for diagnosis and prognosis evaluation of NSCLC.The expression of serum miR-17-5p in NSCLC patients is increased, and it is closely related to the prognosis of patients. |
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