| 陈岳尧,周仕群,符妹丽.百令胶囊联合环孢素A治疗肾病综合征疗效及对凝血和免疫功能的影响.[J].中南医学科学杂志.,2021,(4):468-472. |
| 百令胶囊联合环孢素A治疗肾病综合征疗效及对凝血和免疫功能的影响 |
| Effect of Bailing capsule combined with cyclosporine A on coagulation function and immune function in patients with nephrotic syndrome |
| 投稿时间：2021-01-31 修订日期：2021-03-11 |
| DOI：10.15972/j.cnki.43-1509/r.2021.04.023 |
| 中文关键词: 百令胶囊 环孢素A 肾病综合征 凝血功能 免疫功能 |
| 英文关键词:Bailing capsule cyclosporine A nephrotic syndrome coagulation function immune function |
| 基金项目: |
|
| 摘要点击次数: 335 |
| 全文下载次数: 233 |
| 中文摘要: |
| 目的探讨百令胶囊联合环孢素A治疗肾病综合征疗效及对凝血和免疫功能的影响。 方法随机将84例肾病综合征患者分为两组,对照组42例采用环孢素A治疗,联合组42例采用百令胶囊联合环孢素A治疗。比较两组疗效、凝血功能[纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、T淋巴细胞亚群(CD3＋、CD4＋、CD8＋、CD4＋/CD8＋)、肾功能[血尿素氮(BUN)、血清肌酐(SCr)、血白蛋白(ALB)、24 h尿蛋白定量]及不良反应发生率。 结果联合组总有效率显著高于对照组(P＜0.05)。联合组治疗后PT、APTT均较对照组明显延长,FIB较对照组降低(P＜0.05)。联合组治疗后CD3＋、CD4＋、CD4＋/CD8＋均明显高于对照组,CD8＋显著低于对照组(P＜0.05)。联合组治疗后BUN、SCr、24h尿蛋白定量均明显低于对照组,ALB水平明显高于对照组(P＜0.05)。两组不良反应发生率比较差异无统计学意义(P＞0.05)。 结论百令胶囊联合环孢素A治疗,肾病综合征患者的凝血功能和免疫功能均得到显著改善,疗效明显,且联合治疗未增加不良反应发生风险,值得临床推广。 |
| 英文摘要: |
| To investigate the effect of Bailing capsule combined with cyclosporine A in the treatment of nephrotic syndrome and its influence on coagulation and immune function. Methods84 cases of nephrotic syndrome were randomly divided into two groups, 42 cases in the control group were treated with cyclosporine A, 42 cases in the combined group were treated with Bailing capsule combined with cyclosporine A. The curative effect, coagulation function (fibrinogen (FIB), prothrombin time (PT), activated partial thromboplastin time (APTT)), T lymphocyte subsets (CD3＋, CD4＋, CD8＋, CD4＋/CD8＋), renal function (blood urea nitrogen (BUN), serum creatinine (SCr), serum albumin (ALB), 24 h urinary protein) and the incidence of adverse reactions were compared between the two groups. ResultsThe total effective rate of the combined group was significantly higher than that of the control group(P＜0.05).After treatment, PT and APTT in the combined group were significantly longer than those in the control group, while FIB was lower than that in the control group(P＜0.05). After treatment, CD3＋, CD4＋ and CD4＋/CD8＋ ratio of the combined group were significantly higher than those of the control group, while CD8＋ was significantly lower than that of the control group(P＜0.05). After treatment, BUN, SCr and 24h urinary protein in the combined group were significantly lower than those in the control group, and ALB level was significantly higher than that in the control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05). ConclusionBailing capsule combined with cyclosporine A can significantly improve the coagulation function and immune function of patients with nephrotic syndrome, and the combined treatment does not increase the risk of adverse reactions, which is worthy of clinical promotion. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|