| 刘艳梅.原发性高血压患者ApoA1/ApoB、体位性血压与颈动脉As的关系.[J].中南医学科学杂志.,2021,(4):459-463. |
| 原发性高血压患者ApoA1/ApoB、体位性血压与颈动脉As的关系 |
| Relationship between ApoA1/ApoB, postural blood pressure and carotid atherosclerosis in patients with essential hypertension |
| 投稿时间：2021-01-25 修订日期：2021-02-02 |
| DOI：10.15972/j.cnki.43-1509/r.2021.04.021 |
| 中文关键词: 原发性高血压 载脂蛋白A1/载脂蛋白B 颈动脉As 体位性血压 |
| 英文关键词:essential hypertension ApoA1/ApoB carotid atherosclerosis postural blood pressure state |
| 基金项目: |
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| 中文摘要: |
| 目的探讨原发性高血压(EH)患者载脂蛋白A1/载脂蛋白B(ApoA1/ApoB)、体位性血压与颈动脉粥样硬化(As)的关系。 方法选取EH合并颈动脉As患者50例为合并As组,另选同期无颈动脉As的EH患者50例为EH组。比较两组患者ApoA1/ApoB、体位性血压、血压变异性(CV),并分析其与颈动脉As的相关性。 结果合并As组HDL、ApoB较EH组低(P＜0.05),ApoA1、ApoA1/ApoB较EH组高(P＜0.05)。体位性血压状态中,合并As组卧位收缩压和卧位舒张压均较EH组高(P＜0.05)。ApoA1/ApoB与颈动脉As呈负相关(P＜0.05),卧位收缩压、卧位舒张压、24 hSBP-CV、24 hDBP-CV与颈动脉As呈正相关(P＜0.05)。多因素分析中,ApoA1/ApoB、卧位收缩压、卧位舒张压是颈动脉As的独立影响因素(P＜0.05)。ApoA1/ApoB、卧位收缩压、卧位舒张压、24 hSBP-CV、24 hDBP-CV预测颈动脉As发生的AUC分别为0.709、0.659、0.636、0.686和0.628。 结论ApoA1/ApoB、体位性血压与EH合并颈动脉As有关,对ApoA1/ApoB和体位性血压高的EH患者要及时干预治疗,防止不良疾病预后的发生。 |
| 英文摘要: |
| To investigate the relationship between apolipoprotein A1/apolipoprotein B (ApoA1/ApoB), postural blood pressure and carotid atherosclerosis (As) in patients with essential hypertension. Methods50 patients with essential hypertension (EH) and carotid atherosclerosis were selected as the As group, and another 50 patients without carotid atherosclerosis were selected as the EH group. ApoA1/ApoB, postural blood pressure and blood pressure variability (CV) were compared between the two groups, and their correlation with carotid atherosclerosis was analyzed. ResultsHDL and ApoB in As group were lower than those in EH group (P＜0.05), and ApoA1 and ApoA1/ApoB were higher than those in EH group (P＜0.05). The systolic and diastolic blood pressure in supine position in As group were higher than those in EH group (P＜0.05). There was a negative correlation between ApoA1/ApoB and carotid atherosclerosis (P＜0.05), and a positive correlation between supine systolic and diastolic blood pressure, 24 hSBP-CV, 24 hDBP-CV and carotid atherosclerosis (P＜0.05). In multivariate analysis, ApoA1/ApoB, supine systolic and diastolic blood pressure were independent influencing factors of carotid atherosclerosis (P＜0.05). The AUC of ApoA1/ApoB, supine systolic and diastolic blood pressure, 24 hSBP-CV and 24 hDBP-CV in predicting carotid atherosclerosis were 0.709,0.659,0.636,0.686 and 0.628, respectively. ConclusionApoA1/ApoB and orthostatic blood pressure are related to EH complicated with carotid atherosclerosis. It should be paid more attention to the patients with ApoA1/ApoB and orthostatic high blood pressure, and intervened in time to prevent the occurrence of adverse disease prognosis. |
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