| 湛文世,王龙,凌小元,马米果,张泰胜.胰岛素泵强化治疗对初诊2型糖尿病患者糖脂代谢及胰岛β细胞功能的影响.[J].中南医学科学杂志.,2021,(4):427-430. |
| 胰岛素泵强化治疗对初诊2型糖尿病患者糖脂代谢及胰岛β细胞功能的影响 |
| Effects of intensive insulin pump therapy on glucose and lipid metabolism and islet β-cell function in newly diagnosed type 2 diabetes mellitus |
| 投稿时间：2020-11-13 修订日期：2020-12-31 |
| DOI：10.15972/j.cnki.43-1509/r.2021.04.013 |
| 中文关键词: 2型糖尿病 初诊患者 胰岛素泵 血糖 血脂 胰岛β细胞功能 |
| 英文关键词:type 2 diabetes mellitus newly diagnosed patients insulin pump blood glucose blood lipid islet β cell function |
| 基金项目:海南省医药卫生科研项目(1904320244A2001) |
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| 中文摘要: |
| 目的探讨胰岛素泵强化治疗对初诊2型糖尿病(T2DM)患者糖脂代谢及胰岛β细胞功能的影响,旨在为临床治疗提供参考。方法选取100例T2DM患者,随机分为对照组和实验组,每组各50例。对照组采用三餐前+睡前多次皮下注射胰岛素强化治疗,实验组采用胰岛素泵强化治疗。比较两组患者治疗前后血糖、血脂水平及胰岛β细胞功能。结果两组患者治疗前血糖、血脂水平及胰岛β细胞功能差异无显著性。治疗后,两组患者空腹血糖(FPG)、糖化白蛋白(GA)、餐后2 h血糖(2hPG)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、胰岛素抵抗指数(HOMA-IR)均显著降低,高密度脂蛋白胆固醇(HDLC)、曲线下面积(AUC)、胰岛细胞功能指数(HOMA-β)均明显上升(P＜0.05)；实验组患者FPG、GA、2hPG、TG、TC、LDLC、HOMA-IR明显低于对照组,HDLC、AUC、HOMA-β明显高于对照组(P＜0.05)。两组患者治疗期间不良反应发生率差异无显著性。结论胰岛素泵强化治疗可快速纠正初诊T2DM患者的血糖、血脂异常,改善其胰岛β细胞功能,值得临床推广。 |
| 英文摘要: |
| To explore the effect of intensive treatment with insulin pump on glycolipid and islet β cell function in newly diagnosed type 2 diabetes mellitus, so as to provide reference for clinical application. Methods100 cases newly diagnosed diabetic patients in our hospital were randomly divided into control group and experimental group with 50 cases in each group. The control group was treated with subcutaneous injection of insulin before meals and sleep, the experimental group received intensive treatment with insulin pump, and the treatment course was 2 weeks. The blood glucose, blood lipid and β cell function of the two groups were compared before and after treatment for 2 weeks. ResultsThere was no significant difference in blood glucose, blood lipid and islet β-cell function between the two groups before treatment. After treatment, fasting plasma glucose (FPG), glycated albumin (GA), postprandial blood glucose at 2 h (2hPG), triglycerides (TG), cholesterol (TC), low density lopoprotein cholesterol (LDLC), insulin resistance index (HOMA-IR) were significantly decreased, high density lopoprotein cholesterol (HDLC), area under curve (AUC), islet β cell function index (HOMA-β) were significantly increased (P＜0.05); FPG, GA, 2hPG, TG, TC, LDLC and HOMA-IR of experimental patients were significantly lower than those of control group, while HDLC, AUC and HOMA-β were significantly higher than those of control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups. ConclusionIntensive insulin pump therapy can quickly correct the abnormal blood glucose and blood lipid of newly diagnosed type 2 diabetes, and improve the function of insulin beta cells. It is worthy of promotion in clinical practice. |
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