| 陈妙佳,马思明,李洋,贺芬,彭俊梅,唐国涛,曹轩.以白藜芦醇为结构单元的丹酚酸A类似物的合成及其体外抗氧化作用测定.[J].中南医学科学杂志.,2021,(4):402-405. |
| 以白藜芦醇为结构单元的丹酚酸A类似物的合成及其体外抗氧化作用测定 |
| Synthesis of salvianolic acid A analogues and determination of the free radical scavenge activity using resveratrol as the scaffold |
| 投稿时间：2021-01-17 修订日期：2021-04-23 |
| DOI：10.15972/j.cnki.43-1509/r.2021.04.007 |
| 中文关键词: 丹酚酸A 白藜芦醇 DPPH抗氧化活性 Vilsmeier-Haack反应 |
| 英文关键词:salvianolic acid A resveratrol DPPH antioxidant activity Vilsmeier-Haack reaction |
| 基金项目:湖南省自然科学基金项目(2019JJ50522)；南华大学大学生创新性实验计划项目(2018XJXZ193,X2019182) |
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| 中文摘要: |
| 目的以白藜芦醇为结构单元设计合成丹酚酸A的结构类似物,测定其体外机抗氧化作用。方法通过简单的四步反应进行合成并确定其结构,同时对合成的丹酚酸A类似物进行体外抗氧化1,1-二苯基-2-三硝基苯肼(DPPH)活性测试。结果成功建立丹酚酸A类似物。DPPH抗氧化活性测试结果显示化合物d、e和f的自由基清除率远大于对照品丹酚酸A和抗坏血酸。结论设计合成的丹酚酸A类似物具备极强的抗氧化活性,具有进一步研究的价值。 |
| 英文摘要: |
| A series of structural analogs of salvianolic acid A were synthesized with resveratrol as the scaffold and their antioxidant activity were determined in vitro. MethodsThe salvianolic acid A analogs were synthesized by four-step simple reactions. The antioxidant activity of the analogs was evaluated in vitro for 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH). ResultsThe analogue of salvianolicacid A was succesfully established. DPPH antioxidant activity tests showed that the free radical scavenging rates of compounds d, e and f were much higher than that of salvianolic acid A and ascorbic acid. ConclusionThe designed and synthesized structural analogues of salvianolic acid A have strong antioxidant activity and are worthy of further research. |
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