| 李文川,蔡雪红,陈巍,邱英桓,段小辉,杨尽晖.CHI3L1在肝切除术后参与肝脏血管再生的研究进展.[J].中南医学科学杂志.,2021,(3):363-367. |
| CHI3L1在肝切除术后参与肝脏血管再生的研究进展 |
| Research progress of CHI3L1 involved in hepatic angiogenesis after hepatectomy |
| 投稿时间：2021-01-05 修订日期：2021-03-09 |
| DOI：10.15972/j.cnki.43-1509/r.2021.03.025 |
| 中文关键词: 肝切除术 急性肝损伤 CHI3L1 肝脏肿瘤 血管再生 |
| 英文关键词:hepatectomy acute liver injury CHI3L1 liver neoplasms angiogene |
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| 中文摘要: |
| 壳多糖酶3样蛋白1(CHI3L1)是由肝脏巨噬细胞所分泌的一种糖基水解酶(GH)家族蛋白,是巨噬细胞所分泌的标志性蛋白之一,CHI3L1在机体内发挥了重要的作用,如介导了细胞的氧化应激、炎症反应、修复组织和再生血管等过程。在肝切除术后,肝脏处于急性损伤状态,CHI3L1由巨噬细胞显著表达,后者作为一种血管生成因子,与巨噬细胞、血管内皮生长因子(VEGF)、神经突因子抑制蛋白(Nogo)等协调作用,通过激活多种复杂的信号通路,促进了肝切除术后组织的修复和血管再生。 |
| 英文摘要: |
| Chitosanase 3-like protein 1 (CHI3L1) is a glycosyl hydrolase (GH) family protein secreted by liver macrophages, and it is one of the landmark proteins secreted by macrophages. CHI3L1 plays an important role in the body, such as mediating oxidative stress, inflammatory reaction, Tissue repair and angiogenesis. After hepatectomy, the liver is in a state of acute injury. CHI3L1 is significantly expressed by macrophages. As an angiogenesis factor, CHI3L1 acts in coordination with macrophages, vascular endothelial growth factor (VEGF), nerve process factor inhibitor protein (Nogo) and other factors, and promotes tissue repair and angiogenesis after hepatectomy by activating various complex signal pathways. |
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