| 周榕,崔晓雪,华正东,陈绪发.慢性阻塞性肺疾病合并冠心病患者sTREM-l及炎症状态与冠状动脉病变程度的相关性.[J].中南医学科学杂志.,2021,(3):331-334. |
| 慢性阻塞性肺疾病合并冠心病患者sTREM-l及炎症状态与冠状动脉病变程度的相关性 |
| Correlation between sTREM-l, inflammatory state and severity of coronary artery disease in patients with chronic obstructive pulmonary disease and coronary heart disease |
| 投稿时间：2020-12-07 修订日期：2021-01-20 |
| DOI：10.15972/j.cnki.43-1509/r.2021.03.018 |
| 中文关键词: 慢性阻塞性肺疾病 血清可溶性髓样细胞触发受体-1 冠状动脉粥样硬化 冠心病 炎症因子 |
| 英文关键词:chronic obstructive pulmonary disease sTREM-l coronary atherosclerosis coronary heart disease inflammatory factors |
| 基金项目: |
|
| 摘要点击次数: 515 |
| 全文下载次数: 332 |
| 中文摘要: |
| 目的探讨慢性阻塞性肺疾病合并冠心病患者血清可溶性髓样细胞触发受体-1(sTREM-l)及炎症状态与冠状动脉病变程度的相关性。方法选择50例稳定期慢性阻塞性肺疾病合并冠心病患者以及58例稳定期单纯慢性阻塞性肺疾病患者(COPD组)和60例单纯冠心病患者(CHD组)为研究对象,选择同期60例健康体检者为对照组,采用血细胞自动计数仪检测外周血白细胞(WBC),采用ELISA法检测患者sTREM-l水平、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)等炎症因子水平。采用免疫增强比浊法检测超敏C-反应蛋白(hs-CRP),并行相关性分析。结果COPD组、CHD组和合并冠心病组的WBC、血清sTREM-l以及炎症因子水平明显高于对照组(P＜0.05),COPD组、CHD组和合并冠心病组间比较差异均具有显著性(P＜0.05),CHD组的WBC、血清sTREM-l以及炎症因子水平明显高于COPD组(P＜0.05)。与单支病变比较,双支病变和三支病变患者的WBC、血清sTREM-l以及炎症因子水平明显高于单支病变患者(P＜0.05),双支病变和三支病变患者间比较差异有显著性(P＜0.05)。相关性分析显示,WBC、sTREM-l和hs-CRP与冠状动脉病变程度正相关(r＝0.679,0.824,0.712,P＜0.05)。多元逐步回归分析显示WBC、血清sTREM-l以及炎症因子水平与冠心病不同病情严重程度密切相关(P＜0.05)。结论慢性阻塞性肺疾病合并冠心病患者的WBC、血清sTREM-l及炎症因子水平升高,血清sTREM-l以及炎症因子hs-CRP水平与冠心病不同病情严重程度密切相关。 |
| 英文摘要: |
| To investigate the correlation of sTREM-l and inflammatory status with the severity of coronary artery disease in patients with chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD). Methods50 patients of chronic obstructive pulmonary disease with coronary heart disease, 58 patients with stable COPD and 60 patients of CHD were selected, and 60 healthy people in the same period were selected as the control group. Peripheral white blood cells (WBC) were detected by automatic blood cell counter, and sTREM-l level and swelling were detected by ELISA method. Levels of inflammatory factors such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were measured. The high sensitivity C-reactive protein (hs-CRP) was detected by immunoenhancement turbidimetry, and the correlation was analyzed. ResultsThe levels of WBC, serum strem-l and inflammatory factors in simple group, coronary heart disease group and coronary heart disease group were significantly higher than those in control group (P＜0.05). There were significant differences among simple group, coronary heart disease group and coronary heart disease group (P＜0.05). Compared with single vessel disease, the levels of WBC, serum strem-l and inflammatory factors in patients with double vessel disease and three vessel disease were significantly higher than those in patients with single vessel disease (P＜0.05), and there was significant difference between patients with double vessel disease and three vessel disease (P＜0.05). The correlation analysis showed that WBC, sTREM-l and hs-CRP were positively correlated with the severity of coronary artery lesions (r＝0.679,0.824,0.712, P＜0.05). Multiple stepwise regression analysis showed that WBC, serum sTREM-l and inflammatory factors were closely related to the severity of coronary heart disease (P＜0.05). ConclusionThe levels of WBC, sTREM-l and inflammation in chronic obstructive pulmonary disease patients with coronary heart disease are increased, and the levels of sTREM-l and hs-CRP are closely related to the severity of coronary heart disease. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|