| 刘旺,周琴怡,莫志勇,李峰.SIRT1调控氧化应激的研究进展.[J].中南医学科学杂志.,2021,(2):239-243. |
| SIRT1调控氧化应激的研究进展 |
| Research progress on the regulation of oxidative stress by SIRT1 |
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| DOI：10.15972/j.cnki.43-1509/r.2021.02.025 |
| 中文关键词: 沉默信息调节因子1 氧化应激 去乙酰化 [ |
| 英文关键词:SIRT1 oxidative stress deacetylation |
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| 中文摘要: |
| 氧化应激损伤是指人体处于氧化应激环境下,体内产生活性氧自由基超过氧化抗氧化系统平衡,导致人体的损伤。沉默信息调节因子1(SIRT1) 属于沉默信息调节因子家族成员,具有去乙酰化酶作用,在许多生物过程中发挥重要作用,包括氧化应激、细胞凋亡和衰老、基因转录、新陈代谢等。近来研究发现,SIRT1 可通过去乙酰化作用调控不同靶基因、靶蛋白,在氧化应激相关疾病中发挥重要作用。本文就SIRT1 对氧化应激的调控进行综述。 |
| 英文摘要: |
| Oxidative stress damage means that the human body is in an oxidative stress environment, and the active oxygen free radicals produced in the body exceed the balance of the oxidative and antioxidant, resulting in damage to the human body. silent information regulator of transcription 1 (SIRT1), a member of the family of silent transcriptional regulators, has the role of deacetylase and plays an important role in many biological processes, including oxidative stress, apoptosis and senescence, gene transcription, metabolism and so on. Recent studies have found that SIRT1 can regulate different target genes and target proteins through deacetylation and play an important role in oxidative stress-related diseases.This article reviews the regulation of oxidative stress by SIRT1. |
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