| 胡凌云,雷娇,唐昕.血清GGT、ApoAⅠ、Visfatin与冠心病患者动脉粥样硬化程度的关系.[J].中南医学科学杂志.,2021,(2):228-232. |
| 血清GGT、ApoAⅠ、Visfatin与冠心病患者动脉粥样硬化程度的关系 |
| Relationship between serum GGT, ApoAⅠ, Visfatin and the degree of atherosclerosis in patients with coronary heart disease |
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| DOI：10.15972/j.cnki.43-1509/r.2021.02.022 |
| 中文关键词: 冠心病 动脉粥样硬化 γ-谷氨酰基转移酶 载脂蛋白AⅠ 内脏脂肪素 [ |
| 英文关键词:coronary heart disease atherosclerosis gamma-glutamyltransferase apolipoprotein AⅠ Visfatin |
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| 中文摘要: |
| 目的分析血清γ-谷氨酰基转移酶(GGT)、载脂蛋白AⅠ(ApoAⅠ)、内脏脂肪素(Visfatin)与冠心病患者冠状动脉粥样硬化程度的关系。方法回顾性分析本院122例冠心病患者临床资料,并纳入行冠状动脉造影检查排除冠心病者32例作为对照组。根据122例患者Gensini评分将其分为轻度病变组、中度病变组、重度病变组。分析冠心病患者动脉粥样硬化程度与血清GGT、ApoAⅠ、Visfatin水平的相关性,并使用受试者工作曲线(ROC)评估上述血清指标及其联合检测对冠心病患者重度动脉粥样硬化病变的诊断价值。结果4组血清GGT、Visfatin水平比较,重度病变组＞中度病变组＞轻度病变组＞对照组(P＜0.05)；血清ApoAⅠ水平比较,重度病变组＜中度病变组＜轻度病变组＜对照组(P＜0.05)。经Pearson相关性分析发现,冠心病患者动脉粥样硬化程度与血清GGT、Visfatin水平呈正相关(r＝0.391、0.428,P＜0.05),与血清ApoAⅠ水平呈负相关(r＝－0.325,P＜0.05)；经ROC曲线分析,血清GGT、ApoAⅠ、Visfatin水平对冠心病患者重度动脉粥样硬化病变均具有较高诊断价值(AUC＝0.701、0.665、0.882,P＜0.05),其cut-off值分别为31.57 U/L、1.30 g/L、59.12 ng/L,且3项联合检测诊断价值最高(AUC＝0.919,P＜0.05)。结论血清GGT、ApoAⅠ、Visfatin水平与冠心病患者动脉粥样硬化程度密切相关,且能辅助鉴别重度动脉粥样硬化病变,有望成为冠心病的新诊疗指标。 |
| 英文摘要: |
| To analyze the relationship between serum gamma-glutamyltransferase (GGT), apolipoprotein AⅠ (ApoAⅠ) and Visfatin and atherosclerosis degree in patients with coronary heart disease. MethodsThe clinical data of 122 patients with coronary heart disease in our hospital were retrospectively analyzed, and 32 people who underwent coronary angiography excluding CHD were included as control group. According to the Gensini score of 122 patients, they were divided into mild disease group, moderate disease group, and severe disease group. The correlation between atherosclerosis degree and levels of serum GGT, ApoAⅠand Visfatin in patients with coronary heart disease was analyzed, and the receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic value of above serum indicators and their combined detection on severe atherosclerosis in patients with coronary heart disease. ResultsComparison of serum GGT and Visfatin levels among the four groups showed that severe disease group＞moderate disease group＞mild disease group＞control group (P＜0.05). Comparison of serum ApoAⅠ level showed that severe disease group＜moderate disease group＜mild disease group＜control group (P＜0.05). Pearson correlation analysis showed that the atherosclerosis degree in patients with coronary heart disease was positively correlated with serum GGT and Visfatin levels (r＝0.391,0.428, P＜0.05), and was negatively correlated with serum ApoAⅠ level (r＝－0.325, P＜0.05). After ROC curve analysis, serum GGT, ApoAⅠ, and Visfatin levels had high diagnostic value on severe atherosclerosis in patients with coronary heart disease (AUC＝0.701,0.665,0.882, P＜0.05), and their cut-off values were 31.57 U/L, 1.30 g/L, and 59.12 ng/L respectively, and the three combination of the three had the highest diagnostic value (AUC＝0.919, P＜0.05). ConclusionSerum levels of GGT, ApoAⅠ, and Visfatin are closely related to the atherosclerosis degree in patients with coronary heart disease, and can assist in the identification of severe diseases, and are expected to become new diagnostic and treatment indicators for coronary heart disease. |
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