| 韩鹏飞,孙莉,陈长浩.重复经颅磁刺激联合帕罗西汀治疗女性抑郁症伴功能性胃肠病的疗效及安全性评价.[J].中南医学科学杂志.,2021,(2):173-177. |
| 重复经颅磁刺激联合帕罗西汀治疗女性抑郁症伴功能性胃肠病的疗效及安全性评价 |
| Efficacy and safety of repetitive transcranial magnetic stimulation combined with paroxetine in the treatment of female patients with depression and functional gastrointestinal disease |
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| DOI：10.15972/j.cnki.43-1509/r.2021.02.011 |
| 中文关键词: 重复经颅磁刺激 帕罗西汀 抑郁症 功能性胃肠病 [ |
| 英文关键词:repetitive transcranial magnetic stimulation paroxetine depression functional gastrointestinal disease |
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| 中文摘要: |
| 目的观察重复经颅磁刺激联合帕罗西汀治疗女性抑郁症伴功能性胃肠病的疗效及安全性,并分析其作用机制。方法选取女性抑郁症伴功能性胃肠病患者60例,随机分为对照组及颅磁组(n＝30)。对照组患者口服帕罗西汀治疗,颅磁组在对照组的基础上重复经颅磁刺激治疗。比较两组治疗前及治疗1周、2周、4周后抑郁、胃肠道症状改善情况,于治疗4周后评估治疗效果及不良反应情况；比较两组治疗前、治疗4周后神经内分泌指标多巴胺、5-羟色胺(5-HT)、皮质醇 变化情况。结果治疗1周、2周、4周后,两组间汉密尔顿抑郁量表-17项(HAMD-17)、胃肠道症状评定量表(GSRS)评分差异有显著性(P＜0.05),且颅磁组低于对照组；治疗4周后,颅磁组总有效率高于对照组(P＜0.05)；两组不良反应发生率比较,差异无显著性(P＞0.05)；治疗4周后,颅磁组血清多巴胺、5-HT高于对照组,皮质醇低于对照组(P＜0.05)。结论在帕罗西汀治疗的基础上联合重复经颅磁刺激有利于改善女性抑郁症伴功能性胃肠病患者抑郁及胃肠道症状,提高治疗效果,其机制可能与重复经颅磁刺激改善神经内分泌指标相关；且该疗法具有较高的安全性。 |
| 英文摘要: |
| To investigate the efficacy and safety of repetitive transcranial magnetic stimulation combined with paroxetine in the treatment of female patients with depression and functional gastrointestinal disease, then analyze its mechanism. MethodsSixty female patients with depression and functional gastrointestinal disease were selected and they were randomly divided into control group and observation group, with 30 cases in each group. The control group was treated with paroxetine, and the observation group was treated with repetitive transcranial magnetic stimulation and paroxetine. The improvement of depression and gastrointestinal symptoms before treatment and after 1 week, 2 weeks and 4 weeks of treatment were compared between the two groups, and the treatment effect was evaluated after 4 weeks of treatment and the adverse reactions during treatment were tracked and evaluated; the changes of neuroendocrine indexes before and after 4 weeks of treatment were compared between the two groups. ResultsAfter 1 week, 2 weeks and 4 weeks of treatment, there were significant differences in Hamilton Depression Scale-17 (HAMD-17) and gastrointestinal symptom score (GSRS) between the two groups (P＜0.05), and the observation group was lower than the control group; after 4 weeks of treatment, the total effective rate in the observation group was higher than that in the control group (P＜0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05); after 4 weeks of treatment, the neuroendocrine indexes [dopamine (DA), 5-hydroxytryptamine (5-HT), cortisol] were statistically significant (P＜0.05), DA and 5-HT in the observation group were higher than those in the control group, and cortisol was lower than that in the control group. ConclusionParoxetine treatment combined with repetitive transcranial magnetic stimulation can improve the depression and gastrointestinal symptoms of female depression patients with functional gastrointestinal disease, and improve the treatment effect. The mechanism may be related to the improvement of neuroendocrine indexes by repetitive transcranial magnetic stimulation. At the same time, the therapy has relatively high safety. |
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