| 尹红亚,童重新,何瑞芝,高芳,刘会雪.血清IL-17及TGF-β细胞因子与未足月胎膜早破并发组织学绒毛膜羊膜炎的关系.[J].中南医学科学杂志.,2021,(1):63-67. |
| 血清IL-17及TGF-β细胞因子与未足月胎膜早破并发组织学绒毛膜羊膜炎的关系 |
| Relationship between serum IL-17, TGF-β cytokines and histologic chorioamnionitis in preterm premature rupture of membranes |
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| DOI：10.15972/j.cnki.43-1509/r.2021.01.012 |
| 中文关键词: 未足月胎膜早破 白细胞介素-17 转化生长因子-β 绒毛膜羊膜炎 |
| 英文关键词:preterm premature rupture of membranes IL-17 TGF-β histologic chorioamnionitis |
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| 中文摘要: |
| 目的探讨血清白细胞介素-17(IL-17)及转化生长因子-β(TGF-β)细胞因子与未足月胎膜早破(PPROM)孕妇发生组织学绒毛膜羊膜炎的关系。方法选取98例未足月胎膜早破孕妇和100例健康孕妇,对比其血清Th17细胞因子IL-17及Treg细胞因子TGF-β表达水平的差异。根据PPROM患者后续HCA发生情况分为HCA组(n＝28)、非HCA组(n＝70),采用ROC曲线分析血清IL-17、TGF-β对PPROM患者并发HCA的预测价值,采用单因素、多因素模型分析PPROM患者并发HCA的危险因素。结果PPROM组孕妇入院后早期血清IL-17、TGF-β水平高于对照组(P＜0.05)。ROC曲线显示,IL-17预测PPROM孕妇并发HCA的最佳截断值为13.24 ng/L,AUC为0.825(95%CI:0.740~0.910),对应的灵敏度、特异度分别为62.86%、78.57%；TGF-β预测PPROM孕妇并发HCA的最佳截断值为10.93 ng/L,AUC为0.831(95%CI:0.743~0.919),对应的灵敏度、特异度分别为71.43%、78.57%。Logistic回归分析发现,胎膜早破潜伏时间较长,WBC、CRP、IL-17和TGF-β水平较高均是PPROM孕妇并发HCA的独立危险因素(P＜0.05)。结论入院后早期IL-17及TGF-β水平较高是导致PPROM孕妇并发HCA的独立危险因素之一,且其表达水平可预测PPROM孕妇HCA发生风险。 |
| 英文摘要: |
| To investigate the relationship between serum IL-17 and TGF-β cytokines and histologic chorioamnionitis (HCA) in pregnant women with preterm premature rupture of membranes (PPROM). Methods98 cases of PPROM patients and 100 cases of healthy pregnant women were chosen in our hospital, the levels of serum Th17 cytokine IL-17, Treg cytokine TGF-β were compared between two groups. According to the occurrence of follow-up HCA in PPROM group, they were further divided into HCA group (n＝28) and non-HCA group (n＝70). The ROC curve was used to analyze the predictive value of serum IL-17, TGF-β for HCA complication in PPROM patients, single-factor and multi-factor model were used to analyze the risk factors for HCA complication in PPROM patients. ResultsSerum levels of IL-17 and TGF-β levels of PPROM group were higher than those in normal control group (P＜0.05). ROC curve showed that optimal cut off value of IL-17 predicted HCA in pregnant women with PPROM was 13.24 ng/L, AUC was 0.825(95%CI:0.740~0.910), corresponding sensitivity and specificity were 62.86%, 78.57% respectively. The optimal truncation value of HCA in pregnant women with PPROM predicted by TGF-β was 10.93 ng/L, AUC was 0.831(95%CI:0.743~0.919), corresponding sensitivity and specificity were 71.43%, 78.57% respectively. Logistic regression analysis found that long latent period of premature rupture of membranes, high WBC, CRP, IL-17, TGF-β levels were independent risk factors for HCA in PPROM pregnant women (P＜ 0.05). ConclusionEarly high levels of IL-17, TGF-β after admission are independent risk factors for HCA in PPROM pregnant women, and their specific levels can predict the risk of HCA in PPROM pregnant women. |
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