| 张笑天,张莉莉,孙苏安.miR-34a靶向调控SOX7表达抑制垂体腺瘤细胞增殖.[J].中南医学科学杂志.,2020,(6):588-591, 603. |
| miR-34a靶向调控SOX7表达抑制垂体腺瘤细胞增殖 |
| Inhibitory effect of miR-34a on the proliferation of pituitary adenoma cell by targeting SOX7 |
| 投稿时间：2019-08-15 修订日期：2020-06-01 |
| DOI：10.15972/j.cnki.43-1509/r.2020.06.008 |
| 中文关键词: miR-34a SOX7 垂体腺瘤细胞 增殖 |
| 英文关键词:miR-34a SOX7 pituitary adenoma cell proliferation |
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| 中文摘要: |
| 探讨miR-34a通过靶向调控SOX7表达对垂体腺瘤细胞增殖的影响。结果显示,miR-34a mimics转染组和siRNA-SOX7组细胞活力、S期、G2期分别低于NC-miR-34a转染组和NC-SOX7转染组,细胞凋亡率和G1期分别高于NC-miR-34a转染组和NC-SOX7转染组。miR-34a mimics转染组SOX7 mRNA、SOX7蛋白的相对表达量低于NC-miR-34a转染组。结果表明,miR-34a可以通过靶向抑制SOX7表达抑制垂体腺瘤细胞增殖。 |
| 英文摘要: |
| To investigate the effects of miR-34a on the proliferation of pituitary adenoma cell through the targeted regulation of SOX7 expression. The results showed that the cell vitality, S and G2 phases of the miR-34a mimics transfection group and siRNA-SOX7 transfection group were lower than those of the NC-miR-34a transfection group and the NC-SOX7 transfection group, respectively, and the apoptosis rate and G1 phase were higher than those of the NC-miR-34a transfection group and the NC-SOX7 transfection group, respectively. The relative expression levels of SOX7 mRNA and SOX7 protein in miR-34a mimics transfection group were lower than those in NC-miR-34a transfection group. The results indicated that miR-34a can inhibit the proliferation of pituitary adenoma cell by inhibiting SOX7 expression. |
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