| 曾丽洪,张小团,曾童,刘卓然.生殖支原体感染的临床分布和耐药性分析.[J].中南医学科学杂志.,2020,(5):540-543. |
| 生殖支原体感染的临床分布和耐药性分析 |
| Clinical distribution and antimicrobial resistance of mycoplasma genitalium infection |
| 投稿时间：2020-05-26 修订日期：2020-06-21 |
| DOI：10.15972/j.cnki.43-1509/r.2020.05.024 |
| 中文关键词: 生殖支原体 解脲脲原体 人型支原体 耐药率 |
| 英文关键词:mycoplasma genitalium ureaplasma urealyticum mycoplasma hominis drug resistance rate |
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| 中文摘要: |
| 生殖支原体的感染在临床上非常常见,其耐药率也受到广泛的关注。本文回顾性分析了502例临床疑似生殖支原体感染患者的临床资料和培养结果。共检出生殖支原体阳性334例,阳性率66.5%,年龄中位数为34岁,其中女性阳性率显著高于男性,比例为17.6∶1。生殖支原体的临床分布中以解脲脲原体为主,检出率为87.7%,男女性别构成比无明显差异。生殖支原体对喹诺酮类和大环内酯类的耐药性较高,对克林霉素的耐药率最高,达到53.5%。其中解脲脲原体对加替沙星、左氧氟沙星、阿奇霉素、克拉霉素和红霉素的耐药率均低于10.0%。而人型支原体或人型支原体与解脲脲原体的混合药敏却表现相反,对阿奇霉素、克拉霉素、红霉素和罗红霉素表现为高度耐药,耐药率均大于60.0%。因此,临床应更加关注支原体培养及药敏结果,合理使用抗生素,延缓抗生素耐药。 |
| 英文摘要: |
| Mycoplasma genitalium(MG) infection is very common in clinical patients, and its drug resistance rate has been widely concerned.The clinical data and culture results of 502 patients with suspected MG infection were analyzed retrospectively.Among the 502 patients, 334 were positive for MG culture, with a positive rate of 66.53%. The median age was 34 years old, and the positive rate of females was significantly higher than that of males, with a ratio of 17.6∶1.The clinical distribution of MG was dominated by ureaplasma urealyticum(Uu), the detection rate was 87.72%, and there was no significant difference between male and female.The resistance of MG to quinolones and macrolides was higher, and the resistance rate to clindamycin was the highest (53.5%).The resistance rates of Uu to gatifloxacin, levofloxacin, azithromycin, clarithromycin and erythromycin were all lower than 10%.On the contrary, mycoplasma hominis(Mh) or Uu mixed with Mh showed high drug resistance to azithromycin, clarithromycin, erythromycin and roxithromycin, with drug resistance rate of more than 60%.Therefore, more attention should be paid to the results of MG culture and drug sensitivity in diagnosis and treatment, so as to use antibiotics rationally and delay antibiotic resistance. |
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